Cargando…

Intracellular trafficking of new anticancer therapeutics: antibody–drug conjugates

Antibody–drug conjugate (ADC) is a milestone in targeted cancer therapy that comprises of monoclonal antibodies chemically linked to cytotoxic drugs. Internalization of ADC takes place via clathrin-mediated endocytosis, caveolae-mediated endocytosis, and pinocytosis. Conjugation strategies, endocyto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kalim, Muhammad, Chen, Jie, Wang, Shenghao, Lin, Caiyao, Ullah, Saif, Liang, Keying, Ding, Qian, Chen, Shuqing, Zhan, Jinbiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546728/ https://www.ncbi.nlm.nih.gov/pubmed/28814834 http://dx.doi.org/10.2147/DDDT.S135571

Ejemplares similares

Engineered scPDL1-DM1 drug conjugate with improved in vitro analysis to target PD-L1 positive cancer cells and intracellular trafficking studies in cancer therapy
por: Kalim, Muhammad, et al.
Publicado: (2020)

Dynamics of Endocytosis and Degradation of Antibody-Drug Conjugate T-DM1 in HER2 Positive Cancer Cells
por: Liang, Keying, et al.
Publicado: (2021)

Implications of receptor-mediated endocytosis and intracellular trafficking dynamics in the development of antibody drug conjugates
por: Ritchie, Michael, et al.
Publicado: (2013)

Bioengineering and computational analysis of programmed cell death ligand-1 monoclonal antibody
por: Kalim, Muhammad, et al.
Publicado: (2022)

TCR-mimic antibody-drug conjugates targeting intracellular tumor-specific mutant antigen KRAS G12V mutation
por: Shen, Ying, et al.
Publicado: (2020)

Trafficking of Siderophore Transporters in Saccharomyces cerevisiae and Intracellular Fate of Ferrioxamine B Conjugates
por: Froissard, Marine, et al.
Publicado: (2007)

Intracellular Trafficking Considerations in the Development of Natural Ligand-Drug Molecular Conjugates for Cancer
por: Yoon, Dennis J., et al.
Publicado: (2011)

Intracellular Trafficking Network and Autophagy of PHBHHx Nanoparticles and their Implications for Drug Delivery
por: Sun, Xiangyu, et al.
Publicado: (2019)

A Versatile Chemo-Enzymatic Conjugation Approach Yields Homogeneous and Highly Potent Antibody-Drug Conjugates
por: Xu, Ying, et al.
Publicado: (2017)

A multivalent biparatopic EGFR-targeting nanobody drug conjugate displays potent anticancer activity in solid tumor models
por: Fan, Jiansheng, et al.
Publicado: (2021)

The Role of GSH in Intracellular Iron Trafficking
por: Hider, Robert, et al.
Publicado: (2021)

Intracellular Delivery of Gold Nanocolloids Promoted by a Chemically Conjugated Anticancer Peptide
por: Kapur, Anshika, et al.
Publicado: (2018)

Rapid conjugation of antibodies to toxins to select candidates for the development of anticancer Antibody-Drug Conjugates (ADCs)
por: Hoffmann, Ricarda M., et al.
Publicado: (2020)

A mechanistic study on the cellular uptake, intracellular trafficking, and antisense gene regulation of bottlebrush polymer-conjugated oligonucleotides
por: Zhang, Lei, et al.
Publicado: (2022)

Intracellular trafficking and signaling in development
por: Constam, Daniel B
Publicado: (2009)

Intracellular Trafficking of HBV Particles
por: Jiang, Bingfu, et al.
Publicado: (2020)

Formulation and Intracellular Trafficking of Lipid–Drug Conjugate Nanoparticles Containing a Hydrophilic Antitubercular Drug for Improved Intracellular Delivery to Human Macrophages
por: Pandit, Sayantan, et al.
Publicado: (2020)

A sustained passion for intracellular trafficking
por: Miller, Elizabeth A.
Publicado: (2013)

An Update on the Intracellular and Intercellular Trafficking of Carmoviruses
por: Navarro, José A., et al.
Publicado: (2017)

Intracellular Cholesterol Trafficking and Impact in Neurodegeneration
por: Arenas, Fabian, et al.
Publicado: (2017)

Intracellular Trafficking and Translocation of Pertussis Toxin
por: Teter, Ken
Publicado: (2019)

TRAPPC4 regulates the intracellular trafficking of PD-L1 and antitumor immunity
por: Ren, Yimeng, et al.
Publicado: (2021)

Intracellular trafficking of ceramide by ceramide transfer protein
por: Hanada, Kentaro
Publicado: (2010)

Impact of Photosensitizers Activation on Intracellular Trafficking and Viscosity
por: Aubertin, Kelly, et al.
Publicado: (2013)

Uptake and Intracellular Trafficking of Superantigens in Dendritic Cells
por: Ganem, María B., et al.
Publicado: (2013)

Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles
por: Foroozandeh, Parisa, et al.
Publicado: (2018)

Getting there: Thyroid hormone receptor intracellular trafficking
por: Allison, Lizabeth A.
Publicado: (2021)

Craniofacial Diseases Caused by Defects in Intracellular Trafficking
por: Lu, Chung-Ling, et al.
Publicado: (2021)

Intracellular trafficking of HLA-E and its regulation
por: He, Wanlin, et al.
Publicado: (2023)

Virulent Drexlervirial Bacteriophage MSK, Morphological and Genome Resemblance With Rtp Bacteriophage Inhibits the Multidrug-Resistant Bacteria
por: Khan, Muhammad Saleem Iqbal, et al.
Publicado: (2021)

Selective intracellular vaporisation of antibody-conjugated phase-change nano-droplets in vitro
por: Ishijima, A., et al.
Publicado: (2017)

Therapeutic Antibodies against Intracellular Tumor Antigens
por: Trenevska, Iva, et al.
Publicado: (2017)

Anti-EphA10 antibody-conjugated pH-sensitive liposomes for specific intracellular delivery of siRNA
por: Zang, Xinlong, et al.
Publicado: (2016)

Huntingtin-associated protein 1-associated intracellular trafficking in neurodegenerative diseases
por: Chen, Xingxing, et al.
Publicado: (2023)

Spatio-Temporal Pattern of Green Agricultural Science and Technology Progress: A Case Study in Yangtze River Delta of China
por: Qian, Chen, et al.
Publicado: (2022)

The Antitumor Activity of TCR-Mimic Antibody-Drug Conjugates (TCRm-ADCs) Targeting the Intracellular Wilms Tumor 1 (WT1) Oncoprotein
por: Shen, Ying, et al.
Publicado: (2019)

Trafficking of Sendai Virus Nucleocapsids Is Mediated by Intracellular Vesicles
por: Chambers, Raychel, et al.
Publicado: (2010)

Comparison of the Intracellular Trafficking Itinerary of CTLA-4 Orthologues
por: Kaur, Satdip, et al.
Publicado: (2013)

Abrin Immunotoxin: Targeted Cytotoxicity and Intracellular Trafficking Pathway
por: Gadadhar, Sudarshan, et al.
Publicado: (2013)

Intracellular calcium release modulates polycystin-2 trafficking
por: Miyakawa, Ayako, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_bj4ficngelc4nfa11n2vhi59n1