IGF2BP3 as a potential tissue marker for the diagnosis of esophageal high-grade intraepithelial neoplasia

BACKGROUND: The clinical significance of insulin-like growth factor-II mRNA-binding protein-3 (IGF2BP3) in esophageal high-grade intraepithelial neoplasia (HGIN) is not clear. This study was designed to characterize the expression of IGF2BP3 in HGIN. PATIENTS AND METHODS: IGF2BP3 expression was eval...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Jingjing, Ji, Qing, Jiao, Chunhua, Ren, Lihua, Zhao, Ye, Chen, Yanfang, Shi, Ruihua, Feng, Yadong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546816/
https://www.ncbi.nlm.nih.gov/pubmed/28814885
http://dx.doi.org/10.2147/OTT.S141179
_version_ 1783255614953095168
author Zhang, Jingjing
Ji, Qing
Jiao, Chunhua
Ren, Lihua
Zhao, Ye
Chen, Yanfang
Shi, Ruihua
Feng, Yadong
author_facet Zhang, Jingjing
Ji, Qing
Jiao, Chunhua
Ren, Lihua
Zhao, Ye
Chen, Yanfang
Shi, Ruihua
Feng, Yadong
author_sort Zhang, Jingjing
collection PubMed
description BACKGROUND: The clinical significance of insulin-like growth factor-II mRNA-binding protein-3 (IGF2BP3) in esophageal high-grade intraepithelial neoplasia (HGIN) is not clear. This study was designed to characterize the expression of IGF2BP3 in HGIN. PATIENTS AND METHODS: IGF2BP3 expression was evaluated by Western blot analyses in 12 cases and by immunohistochemistry (IHC) in 112 cases. The associations between IGF2BP3 expression in HGIN and the clinicopathological parameters were examined. RESULTS: Moderate to strong IGF2BP3 expression was present in HGIN samples. Using IHC, it was found that IGF2BP3 was positive in 68 (60.71%) cases. Intense IHC of IGF2BP3 in HGIN was associated with a deeper lesion depth, and the lesion depth was the only predictor of the positive expression of IGF2BP3. CONCLUSION: Our results suggested that IGF2BP3 may be a supplementary tissue marker for preoperative diagnosis of HGIN.
format Online
Article
Text
id pubmed-5546816
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-55468162017-08-16 IGF2BP3 as a potential tissue marker for the diagnosis of esophageal high-grade intraepithelial neoplasia Zhang, Jingjing Ji, Qing Jiao, Chunhua Ren, Lihua Zhao, Ye Chen, Yanfang Shi, Ruihua Feng, Yadong Onco Targets Ther Original Research BACKGROUND: The clinical significance of insulin-like growth factor-II mRNA-binding protein-3 (IGF2BP3) in esophageal high-grade intraepithelial neoplasia (HGIN) is not clear. This study was designed to characterize the expression of IGF2BP3 in HGIN. PATIENTS AND METHODS: IGF2BP3 expression was evaluated by Western blot analyses in 12 cases and by immunohistochemistry (IHC) in 112 cases. The associations between IGF2BP3 expression in HGIN and the clinicopathological parameters were examined. RESULTS: Moderate to strong IGF2BP3 expression was present in HGIN samples. Using IHC, it was found that IGF2BP3 was positive in 68 (60.71%) cases. Intense IHC of IGF2BP3 in HGIN was associated with a deeper lesion depth, and the lesion depth was the only predictor of the positive expression of IGF2BP3. CONCLUSION: Our results suggested that IGF2BP3 may be a supplementary tissue marker for preoperative diagnosis of HGIN. Dove Medical Press 2017-08-01 /pmc/articles/PMC5546816/ /pubmed/28814885 http://dx.doi.org/10.2147/OTT.S141179 Text en © 2017 Zhang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Zhang, Jingjing
Ji, Qing
Jiao, Chunhua
Ren, Lihua
Zhao, Ye
Chen, Yanfang
Shi, Ruihua
Feng, Yadong
IGF2BP3 as a potential tissue marker for the diagnosis of esophageal high-grade intraepithelial neoplasia
title IGF2BP3 as a potential tissue marker for the diagnosis of esophageal high-grade intraepithelial neoplasia
title_full IGF2BP3 as a potential tissue marker for the diagnosis of esophageal high-grade intraepithelial neoplasia
title_fullStr IGF2BP3 as a potential tissue marker for the diagnosis of esophageal high-grade intraepithelial neoplasia
title_full_unstemmed IGF2BP3 as a potential tissue marker for the diagnosis of esophageal high-grade intraepithelial neoplasia
title_short IGF2BP3 as a potential tissue marker for the diagnosis of esophageal high-grade intraepithelial neoplasia
title_sort igf2bp3 as a potential tissue marker for the diagnosis of esophageal high-grade intraepithelial neoplasia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546816/
https://www.ncbi.nlm.nih.gov/pubmed/28814885
http://dx.doi.org/10.2147/OTT.S141179
work_keys_str_mv AT zhangjingjing igf2bp3asapotentialtissuemarkerforthediagnosisofesophagealhighgradeintraepithelialneoplasia
AT jiqing igf2bp3asapotentialtissuemarkerforthediagnosisofesophagealhighgradeintraepithelialneoplasia
AT jiaochunhua igf2bp3asapotentialtissuemarkerforthediagnosisofesophagealhighgradeintraepithelialneoplasia
AT renlihua igf2bp3asapotentialtissuemarkerforthediagnosisofesophagealhighgradeintraepithelialneoplasia
AT zhaoye igf2bp3asapotentialtissuemarkerforthediagnosisofesophagealhighgradeintraepithelialneoplasia
AT chenyanfang igf2bp3asapotentialtissuemarkerforthediagnosisofesophagealhighgradeintraepithelialneoplasia
AT shiruihua igf2bp3asapotentialtissuemarkerforthediagnosisofesophagealhighgradeintraepithelialneoplasia
AT fengyadong igf2bp3asapotentialtissuemarkerforthediagnosisofesophagealhighgradeintraepithelialneoplasia

Ejemplares similares