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Efficacy and safety of endoscopic submucosal dissection for superficial cancer of the cervical esophagus

BACKGROUND AND STUDY AIMS : Cervical esophageal cancer (CEC) is a less common form of cancer and often locally advanced at the time of diagnosis; thus, survival rates for patients with CEC remain poor. However, no reports exist on results of endoscopic submucosal dissection (ESD) for superficial can...

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Autores principales: Iizuka, Toshiro, Kikuchi, Daisuke, Hoteya, Shu, Kajiyama, Yoshiaki, Kaise, Mitsuru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: © Georg Thieme Verlag KG 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546892/
https://www.ncbi.nlm.nih.gov/pubmed/28791322
http://dx.doi.org/10.1055/s-0043-112493
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author Iizuka, Toshiro
Kikuchi, Daisuke
Hoteya, Shu
Kajiyama, Yoshiaki
Kaise, Mitsuru
author_facet Iizuka, Toshiro
Kikuchi, Daisuke
Hoteya, Shu
Kajiyama, Yoshiaki
Kaise, Mitsuru
author_sort Iizuka, Toshiro
collection PubMed
description BACKGROUND AND STUDY AIMS : Cervical esophageal cancer (CEC) is a less common form of cancer and often locally advanced at the time of diagnosis; thus, survival rates for patients with CEC remain poor. However, no reports exist on results of endoscopic submucosal dissection (ESD) for superficial cancer at the cervical esophagus. The aim of this retrospective study was to elucidate the clinicopathological features and clinical outcomes of ESD for superficial CEC. PATIENTS AND METHODS:  ESD was performed on 891 lesions (in 662 patients) for superficial esophageal cancer from January 2008 to December 2015. Of these, 45 lesions (45 patients) were enrolled in the case group (CEC), and 405 lesions (375 patients) were enrolled in the control group (superficial cancer in the middle thoracic esophagus). The safety of ESD, including R0 resection rate and adverse events, and the efficacy, such as the local recurrence rate and overall survival rate, were evaluated. RESULTS:  The R0 resection rate was 91.1 % in the case group and 96 % in the control group. The rate of esophageal stricture was significantly higher in the case group (20 %) than in the control group (6.6 %). There was no local recurrence, and the 3-year survival rate was 88.4 % in the case group and 96.7 % in the control group. CONCLUSIONS : ESD for superficial cancer in the cervical esophagus was achieved safely, and successful local control was also confirmed. However, the esophageal stricture after ESD was more frequent.
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spelling pubmed-55468922017-08-08 Efficacy and safety of endoscopic submucosal dissection for superficial cancer of the cervical esophagus Iizuka, Toshiro Kikuchi, Daisuke Hoteya, Shu Kajiyama, Yoshiaki Kaise, Mitsuru Endosc Int Open BACKGROUND AND STUDY AIMS : Cervical esophageal cancer (CEC) is a less common form of cancer and often locally advanced at the time of diagnosis; thus, survival rates for patients with CEC remain poor. However, no reports exist on results of endoscopic submucosal dissection (ESD) for superficial cancer at the cervical esophagus. The aim of this retrospective study was to elucidate the clinicopathological features and clinical outcomes of ESD for superficial CEC. PATIENTS AND METHODS:  ESD was performed on 891 lesions (in 662 patients) for superficial esophageal cancer from January 2008 to December 2015. Of these, 45 lesions (45 patients) were enrolled in the case group (CEC), and 405 lesions (375 patients) were enrolled in the control group (superficial cancer in the middle thoracic esophagus). The safety of ESD, including R0 resection rate and adverse events, and the efficacy, such as the local recurrence rate and overall survival rate, were evaluated. RESULTS:  The R0 resection rate was 91.1 % in the case group and 96 % in the control group. The rate of esophageal stricture was significantly higher in the case group (20 %) than in the control group (6.6 %). There was no local recurrence, and the 3-year survival rate was 88.4 % in the case group and 96.7 % in the control group. CONCLUSIONS : ESD for superficial cancer in the cervical esophagus was achieved safely, and successful local control was also confirmed. However, the esophageal stricture after ESD was more frequent. © Georg Thieme Verlag KG 2017-08 2017-08-07 /pmc/articles/PMC5546892/ /pubmed/28791322 http://dx.doi.org/10.1055/s-0043-112493 Text en © Thieme Medical Publishers
spellingShingle Iizuka, Toshiro
Kikuchi, Daisuke
Hoteya, Shu
Kajiyama, Yoshiaki
Kaise, Mitsuru
Efficacy and safety of endoscopic submucosal dissection for superficial cancer of the cervical esophagus
title Efficacy and safety of endoscopic submucosal dissection for superficial cancer of the cervical esophagus
title_full Efficacy and safety of endoscopic submucosal dissection for superficial cancer of the cervical esophagus
title_fullStr Efficacy and safety of endoscopic submucosal dissection for superficial cancer of the cervical esophagus
title_full_unstemmed Efficacy and safety of endoscopic submucosal dissection for superficial cancer of the cervical esophagus
title_short Efficacy and safety of endoscopic submucosal dissection for superficial cancer of the cervical esophagus
title_sort efficacy and safety of endoscopic submucosal dissection for superficial cancer of the cervical esophagus
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546892/
https://www.ncbi.nlm.nih.gov/pubmed/28791322
http://dx.doi.org/10.1055/s-0043-112493
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