Effective gene editing by high-fidelity base editor 2 in mouse zygotes

Targeted point mutagenesis through homologous recombination has been widely used in genetic studies and holds considerable promise for repairing disease-causing mutations in patients. However, problems such as mosaicism and low mutagenesis efficiency continue to pose challenges to clinical applicati...

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Detalles Bibliográficos
Autores principales: Liang, Puping, Sun, Hongwei, Sun, Ying, Zhang, Xiya, Xie, Xiaowei, Zhang, Jinran, Zhang, Zhen, Chen, Yuxi, Ding, Chenhui, Xiong, Yuanyan, Ma, Wenbin, Liu, Dan, Huang, Junjiu, Songyang, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546933/
https://www.ncbi.nlm.nih.gov/pubmed/28585179
http://dx.doi.org/10.1007/s13238-017-0418-2

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