Cargando…
Inhibition of glycogen synthase kinase-3 by BTA-EG(4) reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer’s disease
Organotypic brain slice culture models provide an alternative to early stage in vivo studies as an integrated tissue system that can recapitulate key disease features, thereby providing an excellent platform for drug screening. We recently described a novel organotypic 3xTg-AD mouse brain slice cult...
Autores principales: | Croft, Cara L., Kurbatskaya, Ksenia, Hanger, Diane P., Noble, Wendy |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547074/ https://www.ncbi.nlm.nih.gov/pubmed/28785087 http://dx.doi.org/10.1038/s41598-017-07906-1 |
Ejemplares similares
-
Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures
por: Croft, Cara L, et al.
Publicado: (2017) -
Functional Implications of Glycogen Synthase Kinase-3-Mediated Tau Phosphorylation
por: Hanger, Diane P., et al.
Publicado: (2011) -
Preparation of organotypic brain slice cultures for the study of Alzheimer’s disease
por: Croft, Cara L., et al.
Publicado: (2018) -
Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain
por: Kurbatskaya, Ksenia, et al.
Publicado: (2016) -
Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer’s disease
por: Atherton, Joe, et al.
Publicado: (2014)