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Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells

Acid ceramidase (AC) is a lysosomal cysteine hydrolase that catalyzes the conversion of ceramide into fatty acid and sphingosine. This reaction lowers intracellular ceramide levels and concomitantly generates sphingosine used for sphingosine-1-phosphate (S1P) production. Since increases in ceramide...

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Detalles Bibliográficos
Autores principales:	Lai, Michele, Realini, Natalia, La Ferla, Marco, Passalacqua, Ilaria, Matteoli, Giulia, Ganesan, Anand, Pistello, Mauro, Mazzanti, Chiara Maria, Piomelli, Daniele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547127/ https://www.ncbi.nlm.nih.gov/pubmed/28785021 http://dx.doi.org/10.1038/s41598-017-07606-w

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