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Early involvement of cellular stress and inflammatory signals in the pathogenesis of tubulointerstitial kidney disease due to UMOD mutations

Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an inherited disorder that causes progressive kidney damage and renal failure. Mutations in the UMOD gene, encoding uromodulin, lead to ADTKD-UMOD related. Uromodulin is a GPI-anchored protein exclusively produced by epithelial cells of...

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Detalles Bibliográficos
Autores principales:	Trudu, Matteo, Schaeffer, Celine, Riba, Michela, Ikehata, Masami, Brambilla, Paola, Messa, Piergiorgio, Martinelli-Boneschi, Filippo, Rastaldi, Maria Pia, Rampoldi, Luca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547146/ https://www.ncbi.nlm.nih.gov/pubmed/28785050 http://dx.doi.org/10.1038/s41598-017-07804-6

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