Recovery from critical illness-induced organ failure: the role of autophagy

Autophagy is a catabolic process by which cells can dispose of damaged content and intracellular microorganisms. Recent evidence implicates autophagy as a crucial repair process necessary to recover from critical illness-induced organ failure. Withholding parenteral nutrition in the acute phase of c...

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Detalles Bibliográficos
Autor principal: Gunst, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547478/
https://www.ncbi.nlm.nih.gov/pubmed/28784175
http://dx.doi.org/10.1186/s13054-017-1786-y
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author Gunst, Jan
author_facet Gunst, Jan
author_sort Gunst, Jan
collection PubMed
description Autophagy is a catabolic process by which cells can dispose of damaged content and intracellular microorganisms. Recent evidence implicates autophagy as a crucial repair process necessary to recover from critical illness-induced organ failure. Withholding parenteral nutrition in the acute phase of critical illness activates autophagy and enhances recovery. Several registered drugs have autophagy-stimulating properties, but all lack specificity and none has been investigated in critically ill patients for this purpose.
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spelling pubmed-55474782017-08-09 Recovery from critical illness-induced organ failure: the role of autophagy Gunst, Jan Crit Care Editorial Autophagy is a catabolic process by which cells can dispose of damaged content and intracellular microorganisms. Recent evidence implicates autophagy as a crucial repair process necessary to recover from critical illness-induced organ failure. Withholding parenteral nutrition in the acute phase of critical illness activates autophagy and enhances recovery. Several registered drugs have autophagy-stimulating properties, but all lack specificity and none has been investigated in critically ill patients for this purpose. BioMed Central 2017-08-07 /pmc/articles/PMC5547478/ /pubmed/28784175 http://dx.doi.org/10.1186/s13054-017-1786-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Editorial
Gunst, Jan
Recovery from critical illness-induced organ failure: the role of autophagy
title Recovery from critical illness-induced organ failure: the role of autophagy
title_full Recovery from critical illness-induced organ failure: the role of autophagy
title_fullStr Recovery from critical illness-induced organ failure: the role of autophagy
title_full_unstemmed Recovery from critical illness-induced organ failure: the role of autophagy
title_short Recovery from critical illness-induced organ failure: the role of autophagy
title_sort recovery from critical illness-induced organ failure: the role of autophagy
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547478/
https://www.ncbi.nlm.nih.gov/pubmed/28784175
http://dx.doi.org/10.1186/s13054-017-1786-y
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