A statistical framework for analyzing deep mutational scanning data

Deep mutational scanning is a widely used method for multiplex measurement of functional consequences of protein variants. We developed a new deep mutational scanning statistical model that generates error estimates for each measurement, capturing both sampling error and consistency between replicat...

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Detalles Bibliográficos
Autores principales: Rubin, Alan F., Gelman, Hannah, Lucas, Nathan, Bajjalieh, Sandra M., Papenfuss, Anthony T., Speed, Terence P., Fowler, Douglas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547491/
https://www.ncbi.nlm.nih.gov/pubmed/28784151
http://dx.doi.org/10.1186/s13059-017-1272-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547491/
https://www.ncbi.nlm.nih.gov/pubmed/28784151
http://dx.doi.org/10.1186/s13059-017-1272-5

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