Interleukin-35 on B cell and T cell induction and regulation

Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transduction of IL-35, the regulation effect of IL-35 on B cells and T cells as well as the adopt...

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Autores principales: Huang, Ai, Cheng, Lin, He, Miao, Nie, Jun, Wang, Jianjun, Jiang, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547520/
https://www.ncbi.nlm.nih.gov/pubmed/28794689
http://dx.doi.org/10.1186/s12950-017-0164-5
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author Huang, Ai
Cheng, Lin
He, Miao
Nie, Jun
Wang, Jianjun
Jiang, Ke
author_facet Huang, Ai
Cheng, Lin
He, Miao
Nie, Jun
Wang, Jianjun
Jiang, Ke
author_sort Huang, Ai
collection PubMed
description Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transduction of IL-35, the regulation effect of IL-35 on B cells and T cells as well as the adoptive transfer of IL-35+ regulatory B cells (Breg), therapeutic prospects of recombinant IL-35 (rIL-35) and IL-35 regulation role in various diseases. B-cell regulation expands the regulatory range of IL-35 and alters the view that IL-10 is the chief immune mechanism for Breg cells which secrete IL-35. IL-35 induces Breg cells, which then can induce Treg cells. IL-35 also plays an immunomodulatory role in the human body.
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spelling pubmed-55475202017-08-09 Interleukin-35 on B cell and T cell induction and regulation Huang, Ai Cheng, Lin He, Miao Nie, Jun Wang, Jianjun Jiang, Ke J Inflamm (Lond) Review Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transduction of IL-35, the regulation effect of IL-35 on B cells and T cells as well as the adoptive transfer of IL-35+ regulatory B cells (Breg), therapeutic prospects of recombinant IL-35 (rIL-35) and IL-35 regulation role in various diseases. B-cell regulation expands the regulatory range of IL-35 and alters the view that IL-10 is the chief immune mechanism for Breg cells which secrete IL-35. IL-35 induces Breg cells, which then can induce Treg cells. IL-35 also plays an immunomodulatory role in the human body. BioMed Central 2017-08-07 /pmc/articles/PMC5547520/ /pubmed/28794689 http://dx.doi.org/10.1186/s12950-017-0164-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Huang, Ai
Cheng, Lin
He, Miao
Nie, Jun
Wang, Jianjun
Jiang, Ke
Interleukin-35 on B cell and T cell induction and regulation
title Interleukin-35 on B cell and T cell induction and regulation
title_full Interleukin-35 on B cell and T cell induction and regulation
title_fullStr Interleukin-35 on B cell and T cell induction and regulation
title_full_unstemmed Interleukin-35 on B cell and T cell induction and regulation
title_short Interleukin-35 on B cell and T cell induction and regulation
title_sort interleukin-35 on b cell and t cell induction and regulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547520/
https://www.ncbi.nlm.nih.gov/pubmed/28794689
http://dx.doi.org/10.1186/s12950-017-0164-5
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AT hemiao interleukin35onbcellandtcellinductionandregulation
AT niejun interleukin35onbcellandtcellinductionandregulation
AT wangjianjun interleukin35onbcellandtcellinductionandregulation
AT jiangke interleukin35onbcellandtcellinductionandregulation

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