Tumor cell-intrinsic PD-L1 promotes tumor-initiating cell generation and functions in melanoma and ovarian cancer

As tumor PD-L1 provides signals to anti-tumor PD-1(+) T cells that blunt their functions, αPD-1 and αPD-L1 antibodies have been developed as anti-cancer immunotherapies based on interrupting this signaling axis. However, tumor cell-intrinsic PD-L1 signals also regulate immune-independent tumor cell...

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Detalles Bibliográficos
Autores principales: Gupta, Harshita B, Clark, Curtis A, Yuan, Bin, Sareddy, Gangadhara, Pandeswara, Srilakshmi, Padron, Alvaro S, Hurez, Vincent, Conejo-Garcia, José, Vadlamudi, Ratna, Li, Rong, Curiel, Tyler J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547561/
https://www.ncbi.nlm.nih.gov/pubmed/28798885
http://dx.doi.org/10.1038/sigtrans.2016.30

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