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Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial
BACKGROUND: DC derived-exosomes are nanomeric vesicles harboring functional MHC/peptide complexes capable of promoting T cell immune responses and tumor rejection. Here we report the feasability and safety of the first Phase I clinical trial using autologous exosomes pulsed with MAGE 3 peptides for...
Autores principales: | Escudier, Bernard, Dorval, Thierry, Chaput, Nathalie, André, Fabrice, Caby, Marie-Pierre, Novault, Sophie, Flament, Caroline, Leboulaire, Christophe, Borg, Christophe, Amigorena, Sebastian, Boccaccio, Catherine, Bonnerot, Christian, Dhellin, Olivier, Movassagh, Mojgan, Piperno, Sophie, Robert, Caroline, Serra, Vincent, Valente, Nancy, Le Pecq, Jean-Bernard, Spatz, Alain, Lantz, Olivier, Tursz, Thomas, Angevin, Eric, Zitvogel, Laurence |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC554765/ https://www.ncbi.nlm.nih.gov/pubmed/15740633 http://dx.doi.org/10.1186/1479-5876-3-10 |
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