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Preparation of Galla Chinensis Oral Solution as well as Its Stability, Safety, and Antidiarrheal Activity Evaluation
BACKGROUND OF THE STUDY: As a widely used traditional medicine, Galla Chinensis is rich in tannins. However, there are few detailed studies about pharmaceutical preparations of Galla Chinensis tannin extract (GTE). In the present experiments, for better application and to investigate the possibility...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547719/ https://www.ncbi.nlm.nih.gov/pubmed/28811824 http://dx.doi.org/10.1155/2017/1851459 |
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author | Yang, Yi Luo, Huihui Song, Xu Yu, Li Xie, Juan Yang, Jiajie Jia, Renyong Lin, Juchun Zou, Yuanfeng Li, Lixia Yin, Lizi He, Changliang Liang, Xiaoxia Yue, Guizhou Yin, Zhongqiong |
author_facet | Yang, Yi Luo, Huihui Song, Xu Yu, Li Xie, Juan Yang, Jiajie Jia, Renyong Lin, Juchun Zou, Yuanfeng Li, Lixia Yin, Lizi He, Changliang Liang, Xiaoxia Yue, Guizhou Yin, Zhongqiong |
author_sort | Yang, Yi |
collection | PubMed |
description | BACKGROUND OF THE STUDY: As a widely used traditional medicine, Galla Chinensis is rich in tannins. However, there are few detailed studies about pharmaceutical preparations of Galla Chinensis tannin extract (GTE). In the present experiments, for better application and to investigate the possibility that Galla Chinensis tannin extract can be used as an antidiarrheal drug, we prepared Galla Chinensis oral solution (GOS). MATERIALS AND METHODS: GOS was prepared with GTE, and its physicochemical and microbiological stability was evaluated. The oral acute toxicity of GOS was calculated by the 50% lethal dose (LD(50)). The antidiarrheal activity was determined in a castor oil-induced diarrhea model in mice through diarrhea symptoms, fluid accumulation ratio, and percentage of distance moved by charcoal meal. RESULTS: The tannin content of GTE was 47.75%. GOS could endure a high temperature without a significant decrease of tannin content. After storage for six months, the tannin content of GOS was still more than 90%. GOS was determined to be nontoxic. Meanwhile, GOS showed significant antidiarrheal activity in a castor oil-induced diarrhea model in mice (P < 0.01). CONCLUSION: The results suggested that GOS is an effective and stable antidiarrheal drug that can be used to complement other therapies. |
format | Online Article Text |
id | pubmed-5547719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-55477192017-08-15 Preparation of Galla Chinensis Oral Solution as well as Its Stability, Safety, and Antidiarrheal Activity Evaluation Yang, Yi Luo, Huihui Song, Xu Yu, Li Xie, Juan Yang, Jiajie Jia, Renyong Lin, Juchun Zou, Yuanfeng Li, Lixia Yin, Lizi He, Changliang Liang, Xiaoxia Yue, Guizhou Yin, Zhongqiong Evid Based Complement Alternat Med Research Article BACKGROUND OF THE STUDY: As a widely used traditional medicine, Galla Chinensis is rich in tannins. However, there are few detailed studies about pharmaceutical preparations of Galla Chinensis tannin extract (GTE). In the present experiments, for better application and to investigate the possibility that Galla Chinensis tannin extract can be used as an antidiarrheal drug, we prepared Galla Chinensis oral solution (GOS). MATERIALS AND METHODS: GOS was prepared with GTE, and its physicochemical and microbiological stability was evaluated. The oral acute toxicity of GOS was calculated by the 50% lethal dose (LD(50)). The antidiarrheal activity was determined in a castor oil-induced diarrhea model in mice through diarrhea symptoms, fluid accumulation ratio, and percentage of distance moved by charcoal meal. RESULTS: The tannin content of GTE was 47.75%. GOS could endure a high temperature without a significant decrease of tannin content. After storage for six months, the tannin content of GOS was still more than 90%. GOS was determined to be nontoxic. Meanwhile, GOS showed significant antidiarrheal activity in a castor oil-induced diarrhea model in mice (P < 0.01). CONCLUSION: The results suggested that GOS is an effective and stable antidiarrheal drug that can be used to complement other therapies. Hindawi 2017 2017-07-25 /pmc/articles/PMC5547719/ /pubmed/28811824 http://dx.doi.org/10.1155/2017/1851459 Text en Copyright © 2017 Yi Yang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yang, Yi Luo, Huihui Song, Xu Yu, Li Xie, Juan Yang, Jiajie Jia, Renyong Lin, Juchun Zou, Yuanfeng Li, Lixia Yin, Lizi He, Changliang Liang, Xiaoxia Yue, Guizhou Yin, Zhongqiong Preparation of Galla Chinensis Oral Solution as well as Its Stability, Safety, and Antidiarrheal Activity Evaluation |
title | Preparation of Galla Chinensis Oral Solution as well as Its Stability, Safety, and Antidiarrheal Activity Evaluation |
title_full | Preparation of Galla Chinensis Oral Solution as well as Its Stability, Safety, and Antidiarrheal Activity Evaluation |
title_fullStr | Preparation of Galla Chinensis Oral Solution as well as Its Stability, Safety, and Antidiarrheal Activity Evaluation |
title_full_unstemmed | Preparation of Galla Chinensis Oral Solution as well as Its Stability, Safety, and Antidiarrheal Activity Evaluation |
title_short | Preparation of Galla Chinensis Oral Solution as well as Its Stability, Safety, and Antidiarrheal Activity Evaluation |
title_sort | preparation of galla chinensis oral solution as well as its stability, safety, and antidiarrheal activity evaluation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547719/ https://www.ncbi.nlm.nih.gov/pubmed/28811824 http://dx.doi.org/10.1155/2017/1851459 |
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