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Bartonella quintana, an Unrecognized Cause of Infective Endocarditis in Children in Ethiopia

Bartonella quintana endocarditis, a common cause of culture-negative endocarditis in adults, has rarely been reported in children. We describe 5 patients 7–16 years of age from Ethiopia with heart defects and endocarditis; 4 cases were caused by infection with B. quintana and 1 by Bartonella of unde...

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Autores principales: Tasher, Diana, Raucher-Sternfeld, Alona, Tamir, Akiva, Giladi, Michael, Somekh, Eli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547792/
https://www.ncbi.nlm.nih.gov/pubmed/28730981
http://dx.doi.org/10.3201/eid2308.161037
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author Tasher, Diana
Raucher-Sternfeld, Alona
Tamir, Akiva
Giladi, Michael
Somekh, Eli
author_facet Tasher, Diana
Raucher-Sternfeld, Alona
Tamir, Akiva
Giladi, Michael
Somekh, Eli
author_sort Tasher, Diana
collection PubMed
description Bartonella quintana endocarditis, a common cause of culture-negative endocarditis in adults, has rarely been reported in children. We describe 5 patients 7–16 years of age from Ethiopia with heart defects and endocarditis; 4 cases were caused by infection with B. quintana and 1 by Bartonella of undetermined species. All 5 patients were afebrile and oligosymptomatic, although 3 had heart failure. C-reactive protein was normal or slightly elevated, and erythrocyte sedimentation rate was high. The diagnosis was confirmed by echocardiographic demonstration of vegetations, the presence of high Bartonella IgG titers, and identification of B. quintana DNA in excised vegetations. Embolic events were diagnosed in 2 patients. Our data suggest that B. quintana is not an uncommon cause of native valve endocarditis in children in Ethiopia with heart defects and that possible B. quintana infection should be suspected and pursued among residents of and immigrants from East Africa, including Ethiopia, with culture-negative endocarditis.
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spelling pubmed-55477922017-08-08 Bartonella quintana, an Unrecognized Cause of Infective Endocarditis in Children in Ethiopia Tasher, Diana Raucher-Sternfeld, Alona Tamir, Akiva Giladi, Michael Somekh, Eli Emerg Infect Dis Synopsis Bartonella quintana endocarditis, a common cause of culture-negative endocarditis in adults, has rarely been reported in children. We describe 5 patients 7–16 years of age from Ethiopia with heart defects and endocarditis; 4 cases were caused by infection with B. quintana and 1 by Bartonella of undetermined species. All 5 patients were afebrile and oligosymptomatic, although 3 had heart failure. C-reactive protein was normal or slightly elevated, and erythrocyte sedimentation rate was high. The diagnosis was confirmed by echocardiographic demonstration of vegetations, the presence of high Bartonella IgG titers, and identification of B. quintana DNA in excised vegetations. Embolic events were diagnosed in 2 patients. Our data suggest that B. quintana is not an uncommon cause of native valve endocarditis in children in Ethiopia with heart defects and that possible B. quintana infection should be suspected and pursued among residents of and immigrants from East Africa, including Ethiopia, with culture-negative endocarditis. Centers for Disease Control and Prevention 2017-08 /pmc/articles/PMC5547792/ /pubmed/28730981 http://dx.doi.org/10.3201/eid2308.161037 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Synopsis
Tasher, Diana
Raucher-Sternfeld, Alona
Tamir, Akiva
Giladi, Michael
Somekh, Eli
Bartonella quintana, an Unrecognized Cause of Infective Endocarditis in Children in Ethiopia
title Bartonella quintana, an Unrecognized Cause of Infective Endocarditis in Children in Ethiopia
title_full Bartonella quintana, an Unrecognized Cause of Infective Endocarditis in Children in Ethiopia
title_fullStr Bartonella quintana, an Unrecognized Cause of Infective Endocarditis in Children in Ethiopia
title_full_unstemmed Bartonella quintana, an Unrecognized Cause of Infective Endocarditis in Children in Ethiopia
title_short Bartonella quintana, an Unrecognized Cause of Infective Endocarditis in Children in Ethiopia
title_sort bartonella quintana, an unrecognized cause of infective endocarditis in children in ethiopia
topic Synopsis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547792/
https://www.ncbi.nlm.nih.gov/pubmed/28730981
http://dx.doi.org/10.3201/eid2308.161037
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