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Acute Febrile Illness and Complications Due to Murine Typhus, Texas, USA,

Murine typhus occurs relatively commonly in southern Texas, as well as in California. We reviewed records of 90 adults and children in whom murine typhus was diagnosed during a 3-year period in 2 hospitals in southern Texas, USA. Most patients lacked notable comorbidities; all were immunocompetent....

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Autores principales: Afzal, Zeeshan, Kallumadanda, Sunand, Wang, Feng, Hemmige, Vagish, Musher, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547806/
https://www.ncbi.nlm.nih.gov/pubmed/28726607
http://dx.doi.org/10.3201/eid2308.161861
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author Afzal, Zeeshan
Kallumadanda, Sunand
Wang, Feng
Hemmige, Vagish
Musher, Daniel
author_facet Afzal, Zeeshan
Kallumadanda, Sunand
Wang, Feng
Hemmige, Vagish
Musher, Daniel
author_sort Afzal, Zeeshan
collection PubMed
description Murine typhus occurs relatively commonly in southern Texas, as well as in California. We reviewed records of 90 adults and children in whom murine typhus was diagnosed during a 3-year period in 2 hospitals in southern Texas, USA. Most patients lacked notable comorbidities; all were immunocompetent. Initial signs and symptoms included fever (99%), malaise (82%), headache (77%), fatigue (70%), myalgias (68%), and rash (39%). Complications, often severe, in 28% of patients included bronchiolitis, pneumonia, meningitis, septic shock, cholecystitis, pancreatitis, myositis, and rhabdomyolysis; the last 3 are previously unreported in murine typhus. Low serum albumin and elevated procalcitonin, consistent with bacterial sepsis, were observed in >70% of cases. Rash was more common in children; thrombocytopenia, hyponatremia, elevated hepatic transaminases, and complications were more frequent in adults. Murine typhus should be considered as a diagnostic possibility in cases of acute febrile illness in southern and even in more northern US states.
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spelling pubmed-55478062017-08-08 Acute Febrile Illness and Complications Due to Murine Typhus, Texas, USA, Afzal, Zeeshan Kallumadanda, Sunand Wang, Feng Hemmige, Vagish Musher, Daniel Emerg Infect Dis Synopsis Murine typhus occurs relatively commonly in southern Texas, as well as in California. We reviewed records of 90 adults and children in whom murine typhus was diagnosed during a 3-year period in 2 hospitals in southern Texas, USA. Most patients lacked notable comorbidities; all were immunocompetent. Initial signs and symptoms included fever (99%), malaise (82%), headache (77%), fatigue (70%), myalgias (68%), and rash (39%). Complications, often severe, in 28% of patients included bronchiolitis, pneumonia, meningitis, septic shock, cholecystitis, pancreatitis, myositis, and rhabdomyolysis; the last 3 are previously unreported in murine typhus. Low serum albumin and elevated procalcitonin, consistent with bacterial sepsis, were observed in >70% of cases. Rash was more common in children; thrombocytopenia, hyponatremia, elevated hepatic transaminases, and complications were more frequent in adults. Murine typhus should be considered as a diagnostic possibility in cases of acute febrile illness in southern and even in more northern US states. Centers for Disease Control and Prevention 2017-08 /pmc/articles/PMC5547806/ /pubmed/28726607 http://dx.doi.org/10.3201/eid2308.161861 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Synopsis
Afzal, Zeeshan
Kallumadanda, Sunand
Wang, Feng
Hemmige, Vagish
Musher, Daniel
Acute Febrile Illness and Complications Due to Murine Typhus, Texas, USA,
title Acute Febrile Illness and Complications Due to Murine Typhus, Texas, USA,
title_full Acute Febrile Illness and Complications Due to Murine Typhus, Texas, USA,
title_fullStr Acute Febrile Illness and Complications Due to Murine Typhus, Texas, USA,
title_full_unstemmed Acute Febrile Illness and Complications Due to Murine Typhus, Texas, USA,
title_short Acute Febrile Illness and Complications Due to Murine Typhus, Texas, USA,
title_sort acute febrile illness and complications due to murine typhus, texas, usa,
topic Synopsis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547806/
https://www.ncbi.nlm.nih.gov/pubmed/28726607
http://dx.doi.org/10.3201/eid2308.161861
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