(−)-Linalool influence on the cerebral blood flow in healthy male volunteers revealed by three-dimensional pseudo-continuous arterial spin labeling

BACKGROUND: Although aromatherapy is widely used, the pharmacology of the essential oils remains undiscovered. AIM: The present study assessed the effect of (−)-linalool, the main contained material of lavender, on the brain function. MATERIALS AND METHODS: Healthy male volunteers calculated the regional cerebral blood flow (CBF) before and after inhalation of (−)-linalool, and CBF changes were evaluated. RESULTS: There were significant CBF reductions in the right superior temporal gyrus to insula, anterior cingulate cortex after inhalation. CONCLUSIONS: The previous study detected the regulatory influence of (−)-linalool on the glutamatergic transmission. The effect of (−)-linalool on the ACC and insula would cause the sedative and anxiolytic activity.