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Piezo1 protein induces the apoptosis of human osteoarthritis-derived chondrocytes by activating caspase-12, the signaling marker of ER stress

The present study was carried out to determine whether the mechanically activated cation channel Piezo1 protein plays a role as a signaling pathway which causes the apoptosis of human chondrocytes. The chondrocytes were isolated, cultured, and then subjected to mechanical stretch force for 0, 2, 12,...

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Detalles Bibliográficos
Autores principales: Li, Xiao-Fei, Zhang, Zhao, Chen, Zhu-Ke, Cui, Zhao-Wei, Zhang, Hai-Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547943/
https://www.ncbi.nlm.nih.gov/pubmed/28731145
http://dx.doi.org/10.3892/ijmm.2017.3075