Telomere length is positively associated with the expression of IL-6 and MIP-1α in bone marrow mesenchymal stem cells of multiple myeloma

Potential roles of mesenchymal stem cells (MSCs) in the pathogenesis of multiple myeloma (MM) are largely unknown. In the current study, the authors analyzed telomere length and the expressions of interleukin (IL)-6 and macrophage inflammatory protein (MIP)-1α in MSCs derived from the bone marrow (BM) of MM patients and controls. The current results demonstrated that there was no significant difference in cell surface expression of CD73 and CD90, and the capacity to differentiate into bone tissue were identified between the BM MSCs derived from MM patients and controls. Interestingly, telomere length (TL) and mRNA expressions of IL-6 and MIP-1α were significantly longer or higher in BM MSCs of MM than those of controls. Moreover, TL is positively associated with the expressions of IL-6 and MIP-1α at the mRNA level in BM MSCs of MM. Additionally, IL-6 and MIP-1α expression were significantly upregulated when MSCs from MM patients were cultured in the myeloma associated condition medium. The present study indicated that myeloma-associated elongation of TL of BM MSCs may be a key element contributing to the increased IL-6 and MIP-1α expression, by which MSCs in the tumor microenvironment may facilitate MM and/or MM bone disease development.