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The Role of the MAPK Signaling, Topoisomerase and Dietary Bioactives in Controlling Cancer Incidence
Reactive oxygen species (ROS) are common products of mitochondrial oxidative phosphorylation, xenobiotics metabolism and are generated in response to several environmental stress conditions. Some of them play important biochemical roles in cellular signal transduction and gene transcription. On the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547980/ https://www.ncbi.nlm.nih.gov/pubmed/28933366 http://dx.doi.org/10.3390/diseases5020013 |
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author | Selim, Khaled A. Abdelrasoul, Hend Aboelmagd, Mohamed Tawila, Ahmed M. |
author_facet | Selim, Khaled A. Abdelrasoul, Hend Aboelmagd, Mohamed Tawila, Ahmed M. |
author_sort | Selim, Khaled A. |
collection | PubMed |
description | Reactive oxygen species (ROS) are common products of mitochondrial oxidative phosphorylation, xenobiotics metabolism and are generated in response to several environmental stress conditions. Some of them play important biochemical roles in cellular signal transduction and gene transcription. On the other hand, ROS are known to be involved in a wide range of human diseases, including cancer. The excessive production of such ROS together with disruption of homeostasis detoxifying mechanisms can mediate a series of cellular oxidative stresses. The oxidative stress of redundant free radicals production can lead to oxidative denaturation of cellular macromolecules including proteins, lipids and DNA. Moreover, oxidative damage is one of the major causes of DNA mutations, replication errors and genomic abnormalities which result in either inhibition or induction of transcription, and end with the disturbance of signal transduction pathways. Among affected signaling pathways are redox-sensitive kinases. The stimulation of these kinases induces several transcription factors through the phosphorylation of their module proteins. The activation of such pathways induces proliferation and cellular transformation. A diet rich in antioxidant compounds has potential health benefits, and there is a growing interest in the role of natural antioxidants in nutrition for prevention and cure of cancer diseases. A controversy has risen regarding the relation between antioxidants and the significant decrease in the risk of cancer incidence. In this review, we will focus on redox-sensitive kinases signaling pathways, highlighting the effects of dietary antioxidant on the prevention, incidence, prognosis or even treatment of human cancers. In addition, we will place emphasis on the chemical classes of pterocarpans as natural anti-oxidants/cancers as well as their underlying mechanisms of action, including their effects on MAPKs and topoisomerase activities. |
format | Online Article Text |
id | pubmed-5547980 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55479802017-09-12 The Role of the MAPK Signaling, Topoisomerase and Dietary Bioactives in Controlling Cancer Incidence Selim, Khaled A. Abdelrasoul, Hend Aboelmagd, Mohamed Tawila, Ahmed M. Diseases Review Reactive oxygen species (ROS) are common products of mitochondrial oxidative phosphorylation, xenobiotics metabolism and are generated in response to several environmental stress conditions. Some of them play important biochemical roles in cellular signal transduction and gene transcription. On the other hand, ROS are known to be involved in a wide range of human diseases, including cancer. The excessive production of such ROS together with disruption of homeostasis detoxifying mechanisms can mediate a series of cellular oxidative stresses. The oxidative stress of redundant free radicals production can lead to oxidative denaturation of cellular macromolecules including proteins, lipids and DNA. Moreover, oxidative damage is one of the major causes of DNA mutations, replication errors and genomic abnormalities which result in either inhibition or induction of transcription, and end with the disturbance of signal transduction pathways. Among affected signaling pathways are redox-sensitive kinases. The stimulation of these kinases induces several transcription factors through the phosphorylation of their module proteins. The activation of such pathways induces proliferation and cellular transformation. A diet rich in antioxidant compounds has potential health benefits, and there is a growing interest in the role of natural antioxidants in nutrition for prevention and cure of cancer diseases. A controversy has risen regarding the relation between antioxidants and the significant decrease in the risk of cancer incidence. In this review, we will focus on redox-sensitive kinases signaling pathways, highlighting the effects of dietary antioxidant on the prevention, incidence, prognosis or even treatment of human cancers. In addition, we will place emphasis on the chemical classes of pterocarpans as natural anti-oxidants/cancers as well as their underlying mechanisms of action, including their effects on MAPKs and topoisomerase activities. MDPI 2017-04-26 /pmc/articles/PMC5547980/ /pubmed/28933366 http://dx.doi.org/10.3390/diseases5020013 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Selim, Khaled A. Abdelrasoul, Hend Aboelmagd, Mohamed Tawila, Ahmed M. The Role of the MAPK Signaling, Topoisomerase and Dietary Bioactives in Controlling Cancer Incidence |
title | The Role of the MAPK Signaling, Topoisomerase and Dietary Bioactives in Controlling Cancer Incidence |
title_full | The Role of the MAPK Signaling, Topoisomerase and Dietary Bioactives in Controlling Cancer Incidence |
title_fullStr | The Role of the MAPK Signaling, Topoisomerase and Dietary Bioactives in Controlling Cancer Incidence |
title_full_unstemmed | The Role of the MAPK Signaling, Topoisomerase and Dietary Bioactives in Controlling Cancer Incidence |
title_short | The Role of the MAPK Signaling, Topoisomerase and Dietary Bioactives in Controlling Cancer Incidence |
title_sort | role of the mapk signaling, topoisomerase and dietary bioactives in controlling cancer incidence |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547980/ https://www.ncbi.nlm.nih.gov/pubmed/28933366 http://dx.doi.org/10.3390/diseases5020013 |
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