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Medication Trials for Hyperphagia and Food-Related Behaviors in Prader–Willi Syndrome
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by the absence of paternally expressed, imprinted genes on chromosome 15q11-13. Individuals with PWS characteristically have poor feeding and lack of appetite in infancy, followed by the development of weight gain and then uncontrol...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548239/ https://www.ncbi.nlm.nih.gov/pubmed/28943610 http://dx.doi.org/10.3390/diseases3020078 |
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author | Miller, Jennifer L. Strong, Theresa V. Heinemann, Janalee |
author_facet | Miller, Jennifer L. Strong, Theresa V. Heinemann, Janalee |
author_sort | Miller, Jennifer L. |
collection | PubMed |
description | Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by the absence of paternally expressed, imprinted genes on chromosome 15q11-13. Individuals with PWS characteristically have poor feeding and lack of appetite in infancy, followed by the development of weight gain and then uncontrolled appetite and lack of satiety, sometime after the age of two. The overwhelming drive to eat is coupled with reduced energy expenditure and decreased caloric requirements, thus, individuals with PWS will become severely obese unless their food intake is strictly controlled. The mechanisms underlying hyperphagia in PWS remain incompletely understood, and to date no drugs have proven effective in controlling appetite. However, clinical trials have started for several medications, which may provide therapeutic options for those with PWS. These medication trials may also provide insight into potential treatments for obesity in the general population. Ideally, these treatments will help alleviate the complex metabolic issues that are part of this syndrome. |
format | Online Article Text |
id | pubmed-5548239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55482392017-09-12 Medication Trials for Hyperphagia and Food-Related Behaviors in Prader–Willi Syndrome Miller, Jennifer L. Strong, Theresa V. Heinemann, Janalee Diseases Review Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by the absence of paternally expressed, imprinted genes on chromosome 15q11-13. Individuals with PWS characteristically have poor feeding and lack of appetite in infancy, followed by the development of weight gain and then uncontrolled appetite and lack of satiety, sometime after the age of two. The overwhelming drive to eat is coupled with reduced energy expenditure and decreased caloric requirements, thus, individuals with PWS will become severely obese unless their food intake is strictly controlled. The mechanisms underlying hyperphagia in PWS remain incompletely understood, and to date no drugs have proven effective in controlling appetite. However, clinical trials have started for several medications, which may provide therapeutic options for those with PWS. These medication trials may also provide insight into potential treatments for obesity in the general population. Ideally, these treatments will help alleviate the complex metabolic issues that are part of this syndrome. MDPI 2015-06-03 /pmc/articles/PMC5548239/ /pubmed/28943610 http://dx.doi.org/10.3390/diseases3020078 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Miller, Jennifer L. Strong, Theresa V. Heinemann, Janalee Medication Trials for Hyperphagia and Food-Related Behaviors in Prader–Willi Syndrome |
title | Medication Trials for Hyperphagia and Food-Related Behaviors in Prader–Willi Syndrome |
title_full | Medication Trials for Hyperphagia and Food-Related Behaviors in Prader–Willi Syndrome |
title_fullStr | Medication Trials for Hyperphagia and Food-Related Behaviors in Prader–Willi Syndrome |
title_full_unstemmed | Medication Trials for Hyperphagia and Food-Related Behaviors in Prader–Willi Syndrome |
title_short | Medication Trials for Hyperphagia and Food-Related Behaviors in Prader–Willi Syndrome |
title_sort | medication trials for hyperphagia and food-related behaviors in prader–willi syndrome |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548239/ https://www.ncbi.nlm.nih.gov/pubmed/28943610 http://dx.doi.org/10.3390/diseases3020078 |
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