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Endocytotic uptake of HPMA-based polymers by different cancer cells: impact of extracellular acidosis and hypoxia

BACKGROUND: Polymeric nanoparticles allow to selectively transport chemotherapeutic drugs to the tumor tissue. These nanocarriers have to be taken up into the cells to release the drug. In addition, tumors often show pathological metabolic characteristics (hypoxia and acidosis) which might affect th...

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Detalles Bibliográficos
Autores principales:	Gündel, Daniel, Allmeroth, Mareli, Reime, Sarah, Zentel, Rudolf, Thews, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548275/ https://www.ncbi.nlm.nih.gov/pubmed/28831253 http://dx.doi.org/10.2147/IJN.S136952

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