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Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus
Adiponectin secreted from the adipocytes plays pleiotropic, anti-atherosclerotic roles, such as enhancement of insulin secretion and an increase in energy expenditure. The measurement of levels of circulating adiponectin is useful to evaluate the progression of atherosclerosis-related diseases, such...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548317/ https://www.ncbi.nlm.nih.gov/pubmed/28936256 http://dx.doi.org/10.5772/63218 |
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author | Hiwasa, Takaki Zhang, Xiao-Meng Kimura, Risa Ohno, Mikiko Chen, Po-Min Nishi, Eiichiro Ono, Koh Kimura, Takeshi Kamitsukasa, Ikuo Wada, Takeshi Aotsuka, Akiyo Mine, Seiichiro Takizawa, Hirotaka Kashiwado, Koichi Takemoto, Minoru Kobayashi, Kazuki Kawamura, Harukiyo Ishibashi, Ryoichi Yokote, Koutaro Nakamura, Rika Tomiyoshi, Go Shinmen, Natsuko Kuroda, Hideyuki |
author_facet | Hiwasa, Takaki Zhang, Xiao-Meng Kimura, Risa Ohno, Mikiko Chen, Po-Min Nishi, Eiichiro Ono, Koh Kimura, Takeshi Kamitsukasa, Ikuo Wada, Takeshi Aotsuka, Akiyo Mine, Seiichiro Takizawa, Hirotaka Kashiwado, Koichi Takemoto, Minoru Kobayashi, Kazuki Kawamura, Harukiyo Ishibashi, Ryoichi Yokote, Koutaro Nakamura, Rika Tomiyoshi, Go Shinmen, Natsuko Kuroda, Hideyuki |
author_sort | Hiwasa, Takaki |
collection | PubMed |
description | Adiponectin secreted from the adipocytes plays pleiotropic, anti-atherosclerotic roles, such as enhancement of insulin secretion and an increase in energy expenditure. The measurement of levels of circulating adiponectin is useful to evaluate the progression of atherosclerosis-related diseases, such as coronary artery disease (CAD), cerebral infarction (CI) and diabetes mellitus (DM). We examined the serum antibody levels against recombinant adiponectin protein via the amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA) method. The results revealed that the antibody levels were significantly higher in patients with CAD, CI and type 2 DM, than in healthy donors. Receiver operating curve analysis showed that the sensitivity was in a range of 41–48% for CAD, CI and DM. Thus, the serum anti-adiponectin antibody levels could be a common marker for atherosclerosis-related diseases. |
format | Online Article Text |
id | pubmed-5548317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-55483172017-09-21 Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus Hiwasa, Takaki Zhang, Xiao-Meng Kimura, Risa Ohno, Mikiko Chen, Po-Min Nishi, Eiichiro Ono, Koh Kimura, Takeshi Kamitsukasa, Ikuo Wada, Takeshi Aotsuka, Akiyo Mine, Seiichiro Takizawa, Hirotaka Kashiwado, Koichi Takemoto, Minoru Kobayashi, Kazuki Kawamura, Harukiyo Ishibashi, Ryoichi Yokote, Koutaro Nakamura, Rika Tomiyoshi, Go Shinmen, Natsuko Kuroda, Hideyuki J Circ Biomark Original Research Article Adiponectin secreted from the adipocytes plays pleiotropic, anti-atherosclerotic roles, such as enhancement of insulin secretion and an increase in energy expenditure. The measurement of levels of circulating adiponectin is useful to evaluate the progression of atherosclerosis-related diseases, such as coronary artery disease (CAD), cerebral infarction (CI) and diabetes mellitus (DM). We examined the serum antibody levels against recombinant adiponectin protein via the amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA) method. The results revealed that the antibody levels were significantly higher in patients with CAD, CI and type 2 DM, than in healthy donors. Receiver operating curve analysis showed that the sensitivity was in a range of 41–48% for CAD, CI and DM. Thus, the serum anti-adiponectin antibody levels could be a common marker for atherosclerosis-related diseases. SAGE Publications 2016-04-07 /pmc/articles/PMC5548317/ /pubmed/28936256 http://dx.doi.org/10.5772/63218 Text en © 2016 Author(s). Licensee InTech. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Article Hiwasa, Takaki Zhang, Xiao-Meng Kimura, Risa Ohno, Mikiko Chen, Po-Min Nishi, Eiichiro Ono, Koh Kimura, Takeshi Kamitsukasa, Ikuo Wada, Takeshi Aotsuka, Akiyo Mine, Seiichiro Takizawa, Hirotaka Kashiwado, Koichi Takemoto, Minoru Kobayashi, Kazuki Kawamura, Harukiyo Ishibashi, Ryoichi Yokote, Koutaro Nakamura, Rika Tomiyoshi, Go Shinmen, Natsuko Kuroda, Hideyuki Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus |
title | Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus |
title_full | Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus |
title_fullStr | Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus |
title_full_unstemmed | Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus |
title_short | Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus |
title_sort | elevated adiponectin antibody levels in sera of patients with atherosclerosis-related coronary artery disease, cerebral infarction and diabetes mellitus |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548317/ https://www.ncbi.nlm.nih.gov/pubmed/28936256 http://dx.doi.org/10.5772/63218 |
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