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Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus

Adiponectin secreted from the adipocytes plays pleiotropic, anti-atherosclerotic roles, such as enhancement of insulin secretion and an increase in energy expenditure. The measurement of levels of circulating adiponectin is useful to evaluate the progression of atherosclerosis-related diseases, such...

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Autores principales: Hiwasa, Takaki, Zhang, Xiao-Meng, Kimura, Risa, Ohno, Mikiko, Chen, Po-Min, Nishi, Eiichiro, Ono, Koh, Kimura, Takeshi, Kamitsukasa, Ikuo, Wada, Takeshi, Aotsuka, Akiyo, Mine, Seiichiro, Takizawa, Hirotaka, Kashiwado, Koichi, Takemoto, Minoru, Kobayashi, Kazuki, Kawamura, Harukiyo, Ishibashi, Ryoichi, Yokote, Koutaro, Nakamura, Rika, Tomiyoshi, Go, Shinmen, Natsuko, Kuroda, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548317/
https://www.ncbi.nlm.nih.gov/pubmed/28936256
http://dx.doi.org/10.5772/63218
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author Hiwasa, Takaki
Zhang, Xiao-Meng
Kimura, Risa
Ohno, Mikiko
Chen, Po-Min
Nishi, Eiichiro
Ono, Koh
Kimura, Takeshi
Kamitsukasa, Ikuo
Wada, Takeshi
Aotsuka, Akiyo
Mine, Seiichiro
Takizawa, Hirotaka
Kashiwado, Koichi
Takemoto, Minoru
Kobayashi, Kazuki
Kawamura, Harukiyo
Ishibashi, Ryoichi
Yokote, Koutaro
Nakamura, Rika
Tomiyoshi, Go
Shinmen, Natsuko
Kuroda, Hideyuki
author_facet Hiwasa, Takaki
Zhang, Xiao-Meng
Kimura, Risa
Ohno, Mikiko
Chen, Po-Min
Nishi, Eiichiro
Ono, Koh
Kimura, Takeshi
Kamitsukasa, Ikuo
Wada, Takeshi
Aotsuka, Akiyo
Mine, Seiichiro
Takizawa, Hirotaka
Kashiwado, Koichi
Takemoto, Minoru
Kobayashi, Kazuki
Kawamura, Harukiyo
Ishibashi, Ryoichi
Yokote, Koutaro
Nakamura, Rika
Tomiyoshi, Go
Shinmen, Natsuko
Kuroda, Hideyuki
author_sort Hiwasa, Takaki
collection PubMed
description Adiponectin secreted from the adipocytes plays pleiotropic, anti-atherosclerotic roles, such as enhancement of insulin secretion and an increase in energy expenditure. The measurement of levels of circulating adiponectin is useful to evaluate the progression of atherosclerosis-related diseases, such as coronary artery disease (CAD), cerebral infarction (CI) and diabetes mellitus (DM). We examined the serum antibody levels against recombinant adiponectin protein via the amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA) method. The results revealed that the antibody levels were significantly higher in patients with CAD, CI and type 2 DM, than in healthy donors. Receiver operating curve analysis showed that the sensitivity was in a range of 41–48% for CAD, CI and DM. Thus, the serum anti-adiponectin antibody levels could be a common marker for atherosclerosis-related diseases.
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spelling pubmed-55483172017-09-21 Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus Hiwasa, Takaki Zhang, Xiao-Meng Kimura, Risa Ohno, Mikiko Chen, Po-Min Nishi, Eiichiro Ono, Koh Kimura, Takeshi Kamitsukasa, Ikuo Wada, Takeshi Aotsuka, Akiyo Mine, Seiichiro Takizawa, Hirotaka Kashiwado, Koichi Takemoto, Minoru Kobayashi, Kazuki Kawamura, Harukiyo Ishibashi, Ryoichi Yokote, Koutaro Nakamura, Rika Tomiyoshi, Go Shinmen, Natsuko Kuroda, Hideyuki J Circ Biomark Original Research Article Adiponectin secreted from the adipocytes plays pleiotropic, anti-atherosclerotic roles, such as enhancement of insulin secretion and an increase in energy expenditure. The measurement of levels of circulating adiponectin is useful to evaluate the progression of atherosclerosis-related diseases, such as coronary artery disease (CAD), cerebral infarction (CI) and diabetes mellitus (DM). We examined the serum antibody levels against recombinant adiponectin protein via the amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA) method. The results revealed that the antibody levels were significantly higher in patients with CAD, CI and type 2 DM, than in healthy donors. Receiver operating curve analysis showed that the sensitivity was in a range of 41–48% for CAD, CI and DM. Thus, the serum anti-adiponectin antibody levels could be a common marker for atherosclerosis-related diseases. SAGE Publications 2016-04-07 /pmc/articles/PMC5548317/ /pubmed/28936256 http://dx.doi.org/10.5772/63218 Text en © 2016 Author(s). Licensee InTech. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Article
Hiwasa, Takaki
Zhang, Xiao-Meng
Kimura, Risa
Ohno, Mikiko
Chen, Po-Min
Nishi, Eiichiro
Ono, Koh
Kimura, Takeshi
Kamitsukasa, Ikuo
Wada, Takeshi
Aotsuka, Akiyo
Mine, Seiichiro
Takizawa, Hirotaka
Kashiwado, Koichi
Takemoto, Minoru
Kobayashi, Kazuki
Kawamura, Harukiyo
Ishibashi, Ryoichi
Yokote, Koutaro
Nakamura, Rika
Tomiyoshi, Go
Shinmen, Natsuko
Kuroda, Hideyuki
Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus
title Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus
title_full Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus
title_fullStr Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus
title_full_unstemmed Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus
title_short Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus
title_sort elevated adiponectin antibody levels in sera of patients with atherosclerosis-related coronary artery disease, cerebral infarction and diabetes mellitus
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548317/
https://www.ncbi.nlm.nih.gov/pubmed/28936256
http://dx.doi.org/10.5772/63218
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