Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Iα (Protein Kinase G Iα)

Arterial hypertension continues to be a major health burden. Development of new antihypertensive drugs that engage vasodilatory mechanisms not harnessed by available therapies offer therapeutic potential. Oxidants induce an interprotein disulfide in PKG Iα (protein kinase G Iα) at C42, which is asso...

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Detalles Bibliográficos
Autores principales: Burgoyne, Joseph R., Prysyazhna, Oleksandra, Richards, Daniel A., Eaton, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott, Williams & Wilkins 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548503/
https://www.ncbi.nlm.nih.gov/pubmed/28716990
http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548503/
https://www.ncbi.nlm.nih.gov/pubmed/28716990
http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09670

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