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Optogenetic study of networks in epilepsy
Currently, approximately 30% of patients with epilepsy do not have adequate seizure control. A greater understanding of the underlying mechanisms by which seizures start or propagate could lead to new therapeutic strategies. The recent development of optogenetics, because of its unprecedented precis...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548626/ https://www.ncbi.nlm.nih.gov/pubmed/27413006 http://dx.doi.org/10.1002/jnr.23767 |
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author | Choy, ManKin Duffy, Ben A. Lee, Jin Hyung |
author_facet | Choy, ManKin Duffy, Ben A. Lee, Jin Hyung |
author_sort | Choy, ManKin |
collection | PubMed |
description | Currently, approximately 30% of patients with epilepsy do not have adequate seizure control. A greater understanding of the underlying mechanisms by which seizures start or propagate could lead to new therapeutic strategies. The recent development of optogenetics, because of its unprecedented precision for controlling activity within distinct neuronal populations, has revolutionized neuroscience, including epilepsy research. This Review discusses recent breakthroughs made with optogenetics in epilepsy research. These breakthroughs include new insights into the key roles that different cell types play in mediating seizures as well as in the development of epilepsy. Subsequently, we discuss how targeting different brain regions and cell populations has opened up the possibility of highly specific therapies that can stop seizures on demand. Finally, we illustrate how combining newly available neuroscience tools with whole‐brain imaging techniques will allow researchers to understand better the spread of seizures on a network level. © 2016 The Authors. Journal of Neuroscience Research Published by Wiley Periodicals, Inc. |
format | Online Article Text |
id | pubmed-5548626 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55486262017-11-01 Optogenetic study of networks in epilepsy Choy, ManKin Duffy, Ben A. Lee, Jin Hyung J Neurosci Res Review Currently, approximately 30% of patients with epilepsy do not have adequate seizure control. A greater understanding of the underlying mechanisms by which seizures start or propagate could lead to new therapeutic strategies. The recent development of optogenetics, because of its unprecedented precision for controlling activity within distinct neuronal populations, has revolutionized neuroscience, including epilepsy research. This Review discusses recent breakthroughs made with optogenetics in epilepsy research. These breakthroughs include new insights into the key roles that different cell types play in mediating seizures as well as in the development of epilepsy. Subsequently, we discuss how targeting different brain regions and cell populations has opened up the possibility of highly specific therapies that can stop seizures on demand. Finally, we illustrate how combining newly available neuroscience tools with whole‐brain imaging techniques will allow researchers to understand better the spread of seizures on a network level. © 2016 The Authors. Journal of Neuroscience Research Published by Wiley Periodicals, Inc. John Wiley and Sons Inc. 2016-07-14 2017-12 /pmc/articles/PMC5548626/ /pubmed/27413006 http://dx.doi.org/10.1002/jnr.23767 Text en © 2016 The Authors. Journal of Neuroscience Research Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Review Choy, ManKin Duffy, Ben A. Lee, Jin Hyung Optogenetic study of networks in epilepsy |
title | Optogenetic study of networks in epilepsy |
title_full | Optogenetic study of networks in epilepsy |
title_fullStr | Optogenetic study of networks in epilepsy |
title_full_unstemmed | Optogenetic study of networks in epilepsy |
title_short | Optogenetic study of networks in epilepsy |
title_sort | optogenetic study of networks in epilepsy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548626/ https://www.ncbi.nlm.nih.gov/pubmed/27413006 http://dx.doi.org/10.1002/jnr.23767 |
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