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Clinical Features, Pathogenesis, and Treatment of Large Granular Lymphocyte Leukemias

Large granular lymphocytes (LGLs) are large lymphocytes with azurophilic granules in their cytoplasm. LGLs are either natural killer (NK) cells or T lymphocytes. Expansions of the LGLs in the peripheral blood are seen in various conditions, including three clonal disorders: T-cell LGL (T-LGL) leukem...

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Autor principal: Oshimi, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548667/
https://www.ncbi.nlm.nih.gov/pubmed/28717070
http://dx.doi.org/10.2169/internalmedicine.56.8881
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author Oshimi, Kazuo
author_facet Oshimi, Kazuo
author_sort Oshimi, Kazuo
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description Large granular lymphocytes (LGLs) are large lymphocytes with azurophilic granules in their cytoplasm. LGLs are either natural killer (NK) cells or T lymphocytes. Expansions of the LGLs in the peripheral blood are seen in various conditions, including three clonal disorders: T-cell LGL (T-LGL) leukemia, chronic lymphoproliferative disorders of NK cells (CLPD-NK), and aggressive NK-cell leukemia (ANKL). However, the monoclonal and polyclonal expansion of LGLs has been associated with many other conditions. The present article describes these LGL disorders, with special emphasis on the clinical features, pathogenesis, and treatments of the three above-mentioned clonal disorders.
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spelling pubmed-55486672017-08-11 Clinical Features, Pathogenesis, and Treatment of Large Granular Lymphocyte Leukemias Oshimi, Kazuo Intern Med Review Article Large granular lymphocytes (LGLs) are large lymphocytes with azurophilic granules in their cytoplasm. LGLs are either natural killer (NK) cells or T lymphocytes. Expansions of the LGLs in the peripheral blood are seen in various conditions, including three clonal disorders: T-cell LGL (T-LGL) leukemia, chronic lymphoproliferative disorders of NK cells (CLPD-NK), and aggressive NK-cell leukemia (ANKL). However, the monoclonal and polyclonal expansion of LGLs has been associated with many other conditions. The present article describes these LGL disorders, with special emphasis on the clinical features, pathogenesis, and treatments of the three above-mentioned clonal disorders. The Japanese Society of Internal Medicine 2017-07-15 /pmc/articles/PMC5548667/ /pubmed/28717070 http://dx.doi.org/10.2169/internalmedicine.56.8881 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Oshimi, Kazuo
Clinical Features, Pathogenesis, and Treatment of Large Granular Lymphocyte Leukemias
title Clinical Features, Pathogenesis, and Treatment of Large Granular Lymphocyte Leukemias
title_full Clinical Features, Pathogenesis, and Treatment of Large Granular Lymphocyte Leukemias
title_fullStr Clinical Features, Pathogenesis, and Treatment of Large Granular Lymphocyte Leukemias
title_full_unstemmed Clinical Features, Pathogenesis, and Treatment of Large Granular Lymphocyte Leukemias
title_short Clinical Features, Pathogenesis, and Treatment of Large Granular Lymphocyte Leukemias
title_sort clinical features, pathogenesis, and treatment of large granular lymphocyte leukemias
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548667/
https://www.ncbi.nlm.nih.gov/pubmed/28717070
http://dx.doi.org/10.2169/internalmedicine.56.8881
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