Pirfenidone-induced Eosinophilic Pleurisy

The patient was a 69-year-old man with idiopathic pulmonary fibrosis who was taking pirfenidone. After 7 weeks of treatment, he suffered from left-sided eosinophilic pleurisy. Medical thoracoscopy was performed and the histopathological examination of the parietal pleura revealed the massive infiltr...

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Detalles Bibliográficos
Autores principales: Hase, Isano, Yamaguchi, Bunpei, Takizawa, Hidenori, Arakawa, Hiroaki, Sakuma, Hideo, Fujiu, Koichi, Miyamoto, Hideaki, Ishii, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548680/
https://www.ncbi.nlm.nih.gov/pubmed/28717083
http://dx.doi.org/10.2169/internalmedicine.56.7738
Descripción
Sumario:The patient was a 69-year-old man with idiopathic pulmonary fibrosis who was taking pirfenidone. After 7 weeks of treatment, he suffered from left-sided eosinophilic pleurisy. Medical thoracoscopy was performed and the histopathological examination of the parietal pleura revealed the massive infiltration of eosinophils and lymphoid follicles. After stopping pirfenidone therapy, the patient's pleural effusion disappeared without additional treatment, and never recurred. This is the first case report of pirfenidone-induced pleurisy.

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