Pirfenidone-induced Eosinophilic Pleurisy

The patient was a 69-year-old man with idiopathic pulmonary fibrosis who was taking pirfenidone. After 7 weeks of treatment, he suffered from left-sided eosinophilic pleurisy. Medical thoracoscopy was performed and the histopathological examination of the parietal pleura revealed the massive infiltr...

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Autores principales: Hase, Isano, Yamaguchi, Bunpei, Takizawa, Hidenori, Arakawa, Hiroaki, Sakuma, Hideo, Fujiu, Koichi, Miyamoto, Hideaki, Ishii, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548680/
https://www.ncbi.nlm.nih.gov/pubmed/28717083
http://dx.doi.org/10.2169/internalmedicine.56.7738
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author Hase, Isano
Yamaguchi, Bunpei
Takizawa, Hidenori
Arakawa, Hiroaki
Sakuma, Hideo
Fujiu, Koichi
Miyamoto, Hideaki
Ishii, Yoshiki
author_facet Hase, Isano
Yamaguchi, Bunpei
Takizawa, Hidenori
Arakawa, Hiroaki
Sakuma, Hideo
Fujiu, Koichi
Miyamoto, Hideaki
Ishii, Yoshiki
author_sort Hase, Isano
collection PubMed
description The patient was a 69-year-old man with idiopathic pulmonary fibrosis who was taking pirfenidone. After 7 weeks of treatment, he suffered from left-sided eosinophilic pleurisy. Medical thoracoscopy was performed and the histopathological examination of the parietal pleura revealed the massive infiltration of eosinophils and lymphoid follicles. After stopping pirfenidone therapy, the patient's pleural effusion disappeared without additional treatment, and never recurred. This is the first case report of pirfenidone-induced pleurisy.
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spelling pubmed-55486802017-08-11 Pirfenidone-induced Eosinophilic Pleurisy Hase, Isano Yamaguchi, Bunpei Takizawa, Hidenori Arakawa, Hiroaki Sakuma, Hideo Fujiu, Koichi Miyamoto, Hideaki Ishii, Yoshiki Intern Med Case Report The patient was a 69-year-old man with idiopathic pulmonary fibrosis who was taking pirfenidone. After 7 weeks of treatment, he suffered from left-sided eosinophilic pleurisy. Medical thoracoscopy was performed and the histopathological examination of the parietal pleura revealed the massive infiltration of eosinophils and lymphoid follicles. After stopping pirfenidone therapy, the patient's pleural effusion disappeared without additional treatment, and never recurred. This is the first case report of pirfenidone-induced pleurisy. The Japanese Society of Internal Medicine 2017-07-15 /pmc/articles/PMC5548680/ /pubmed/28717083 http://dx.doi.org/10.2169/internalmedicine.56.7738 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hase, Isano
Yamaguchi, Bunpei
Takizawa, Hidenori
Arakawa, Hiroaki
Sakuma, Hideo
Fujiu, Koichi
Miyamoto, Hideaki
Ishii, Yoshiki
Pirfenidone-induced Eosinophilic Pleurisy
title Pirfenidone-induced Eosinophilic Pleurisy
title_full Pirfenidone-induced Eosinophilic Pleurisy
title_fullStr Pirfenidone-induced Eosinophilic Pleurisy
title_full_unstemmed Pirfenidone-induced Eosinophilic Pleurisy
title_short Pirfenidone-induced Eosinophilic Pleurisy
title_sort pirfenidone-induced eosinophilic pleurisy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548680/
https://www.ncbi.nlm.nih.gov/pubmed/28717083
http://dx.doi.org/10.2169/internalmedicine.56.7738
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