High-dose Chemotherapy with Stem Cell Rescue Provided Durable Remission for Classical Hodgkin Lymphoma-type Post-transplant Lymphoproliferative Disorder after Unrelated Cord Blood Transplantation: A Case Report and Review of the Literature

An adult woman developed polymorphic post-transplant lymphoproliferative disorder (PTLD) 58 months after unrelated cord blood transplantation. She was treated successfully with chemotherapy and radiation therapy but presented with lymphadenopathy and splenomegaly 74 months after transplantation. A l...

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Autores principales: Itonaga, Hidehiro, Kato, Takeharu, Fujioka, Machiko, Taguchi, Masataka, Taniguchi, Hiroaki, Imaizumi, Yoshitaka, Yoshida, Shinichiro, Miyoshi, Hiroaki, Moriuchi, Yukiyoshi, Ohshima, Koichi, Miyazaki, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548682/
https://www.ncbi.nlm.nih.gov/pubmed/28717085
http://dx.doi.org/10.2169/internalmedicine.56.7938
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author Itonaga, Hidehiro
Kato, Takeharu
Fujioka, Machiko
Taguchi, Masataka
Taniguchi, Hiroaki
Imaizumi, Yoshitaka
Yoshida, Shinichiro
Miyoshi, Hiroaki
Moriuchi, Yukiyoshi
Ohshima, Koichi
Miyazaki, Yasushi
author_facet Itonaga, Hidehiro
Kato, Takeharu
Fujioka, Machiko
Taguchi, Masataka
Taniguchi, Hiroaki
Imaizumi, Yoshitaka
Yoshida, Shinichiro
Miyoshi, Hiroaki
Moriuchi, Yukiyoshi
Ohshima, Koichi
Miyazaki, Yasushi
author_sort Itonaga, Hidehiro
collection PubMed
description An adult woman developed polymorphic post-transplant lymphoproliferative disorder (PTLD) 58 months after unrelated cord blood transplantation. She was treated successfully with chemotherapy and radiation therapy but presented with lymphadenopathy and splenomegaly 74 months after transplantation. A lymph node biopsy confirmed the diagnosis of nodular sclerosis type Hodgkin lymphoma (classical Hodgkin lymphoma [CHL]-type PTLD). After salvage therapy and hematopoietic stem cell harvesting, she was subsequently treated with consolidative high-dose chemotherapy with melphalan followed by stem cell rescue, which resulted in durable remission. High-dose chemotherapy using stem cell rescue has potential as a therapeutic option for subsequent CHL-type PTLD.
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spelling pubmed-55486822017-08-11 High-dose Chemotherapy with Stem Cell Rescue Provided Durable Remission for Classical Hodgkin Lymphoma-type Post-transplant Lymphoproliferative Disorder after Unrelated Cord Blood Transplantation: A Case Report and Review of the Literature Itonaga, Hidehiro Kato, Takeharu Fujioka, Machiko Taguchi, Masataka Taniguchi, Hiroaki Imaizumi, Yoshitaka Yoshida, Shinichiro Miyoshi, Hiroaki Moriuchi, Yukiyoshi Ohshima, Koichi Miyazaki, Yasushi Intern Med Case Report An adult woman developed polymorphic post-transplant lymphoproliferative disorder (PTLD) 58 months after unrelated cord blood transplantation. She was treated successfully with chemotherapy and radiation therapy but presented with lymphadenopathy and splenomegaly 74 months after transplantation. A lymph node biopsy confirmed the diagnosis of nodular sclerosis type Hodgkin lymphoma (classical Hodgkin lymphoma [CHL]-type PTLD). After salvage therapy and hematopoietic stem cell harvesting, she was subsequently treated with consolidative high-dose chemotherapy with melphalan followed by stem cell rescue, which resulted in durable remission. High-dose chemotherapy using stem cell rescue has potential as a therapeutic option for subsequent CHL-type PTLD. The Japanese Society of Internal Medicine 2017-07-15 /pmc/articles/PMC5548682/ /pubmed/28717085 http://dx.doi.org/10.2169/internalmedicine.56.7938 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Itonaga, Hidehiro
Kato, Takeharu
Fujioka, Machiko
Taguchi, Masataka
Taniguchi, Hiroaki
Imaizumi, Yoshitaka
Yoshida, Shinichiro
Miyoshi, Hiroaki
Moriuchi, Yukiyoshi
Ohshima, Koichi
Miyazaki, Yasushi
High-dose Chemotherapy with Stem Cell Rescue Provided Durable Remission for Classical Hodgkin Lymphoma-type Post-transplant Lymphoproliferative Disorder after Unrelated Cord Blood Transplantation: A Case Report and Review of the Literature
title High-dose Chemotherapy with Stem Cell Rescue Provided Durable Remission for Classical Hodgkin Lymphoma-type Post-transplant Lymphoproliferative Disorder after Unrelated Cord Blood Transplantation: A Case Report and Review of the Literature
title_full High-dose Chemotherapy with Stem Cell Rescue Provided Durable Remission for Classical Hodgkin Lymphoma-type Post-transplant Lymphoproliferative Disorder after Unrelated Cord Blood Transplantation: A Case Report and Review of the Literature
title_fullStr High-dose Chemotherapy with Stem Cell Rescue Provided Durable Remission for Classical Hodgkin Lymphoma-type Post-transplant Lymphoproliferative Disorder after Unrelated Cord Blood Transplantation: A Case Report and Review of the Literature
title_full_unstemmed High-dose Chemotherapy with Stem Cell Rescue Provided Durable Remission for Classical Hodgkin Lymphoma-type Post-transplant Lymphoproliferative Disorder after Unrelated Cord Blood Transplantation: A Case Report and Review of the Literature
title_short High-dose Chemotherapy with Stem Cell Rescue Provided Durable Remission for Classical Hodgkin Lymphoma-type Post-transplant Lymphoproliferative Disorder after Unrelated Cord Blood Transplantation: A Case Report and Review of the Literature
title_sort high-dose chemotherapy with stem cell rescue provided durable remission for classical hodgkin lymphoma-type post-transplant lymphoproliferative disorder after unrelated cord blood transplantation: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548682/
https://www.ncbi.nlm.nih.gov/pubmed/28717085
http://dx.doi.org/10.2169/internalmedicine.56.7938
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