Therapy-related Acute Myeloid Leukemia after the Long-term Administration of Low-dose Etoposide for Chronic-type Adult T-cell Leukemia-lymphoma: A Case Report and Literature Review

A 61-year-old woman with chronic-type adult T-cell leukemia-lymphoma (ATL) had been taking low-dose oral etoposide for progressive lymphocytosis. After taking this for 3.5 years, she was diagnosed with therapy-related acute myeloid leukemia (t-AML), with a chromosomal translocation of t (6:11) (q27;...

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Autores principales: Shimada, Naoki, Ohno, Nobuhiro, Tanosaki, Ryuji, Fuji, Shigeo, Suzuki, Yuhko, Yuji, Koichiro, Uchimaru, Kaoru, Tojo, Arinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548683/
https://www.ncbi.nlm.nih.gov/pubmed/28717086
http://dx.doi.org/10.2169/internalmedicine.56.7763
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author Shimada, Naoki
Ohno, Nobuhiro
Tanosaki, Ryuji
Fuji, Shigeo
Suzuki, Yuhko
Yuji, Koichiro
Uchimaru, Kaoru
Tojo, Arinobu
author_facet Shimada, Naoki
Ohno, Nobuhiro
Tanosaki, Ryuji
Fuji, Shigeo
Suzuki, Yuhko
Yuji, Koichiro
Uchimaru, Kaoru
Tojo, Arinobu
author_sort Shimada, Naoki
collection PubMed
description A 61-year-old woman with chronic-type adult T-cell leukemia-lymphoma (ATL) had been taking low-dose oral etoposide for progressive lymphocytosis. After taking this for 3.5 years, she was diagnosed with therapy-related acute myeloid leukemia (t-AML), with a chromosomal translocation of t (6:11) (q27; q23). She thus received remission induction therapy, consolidation therapy, and allogeneic hematopoietic stem cell transplantation. Although both t-AML and ATL were in remissive states, she died of a therapy-related infection within 1 year. We reviewed 12 reported cases of AML complicating ATL to better characterize this unusual disease. We should therefore include t-AML in the differential diagnosis when administering low-dose etoposide for ATL over a long period of time.
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spelling pubmed-55486832017-08-11 Therapy-related Acute Myeloid Leukemia after the Long-term Administration of Low-dose Etoposide for Chronic-type Adult T-cell Leukemia-lymphoma: A Case Report and Literature Review Shimada, Naoki Ohno, Nobuhiro Tanosaki, Ryuji Fuji, Shigeo Suzuki, Yuhko Yuji, Koichiro Uchimaru, Kaoru Tojo, Arinobu Intern Med Case Report A 61-year-old woman with chronic-type adult T-cell leukemia-lymphoma (ATL) had been taking low-dose oral etoposide for progressive lymphocytosis. After taking this for 3.5 years, she was diagnosed with therapy-related acute myeloid leukemia (t-AML), with a chromosomal translocation of t (6:11) (q27; q23). She thus received remission induction therapy, consolidation therapy, and allogeneic hematopoietic stem cell transplantation. Although both t-AML and ATL were in remissive states, she died of a therapy-related infection within 1 year. We reviewed 12 reported cases of AML complicating ATL to better characterize this unusual disease. We should therefore include t-AML in the differential diagnosis when administering low-dose etoposide for ATL over a long period of time. The Japanese Society of Internal Medicine 2017-07-15 /pmc/articles/PMC5548683/ /pubmed/28717086 http://dx.doi.org/10.2169/internalmedicine.56.7763 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Shimada, Naoki
Ohno, Nobuhiro
Tanosaki, Ryuji
Fuji, Shigeo
Suzuki, Yuhko
Yuji, Koichiro
Uchimaru, Kaoru
Tojo, Arinobu
Therapy-related Acute Myeloid Leukemia after the Long-term Administration of Low-dose Etoposide for Chronic-type Adult T-cell Leukemia-lymphoma: A Case Report and Literature Review
title Therapy-related Acute Myeloid Leukemia after the Long-term Administration of Low-dose Etoposide for Chronic-type Adult T-cell Leukemia-lymphoma: A Case Report and Literature Review
title_full Therapy-related Acute Myeloid Leukemia after the Long-term Administration of Low-dose Etoposide for Chronic-type Adult T-cell Leukemia-lymphoma: A Case Report and Literature Review
title_fullStr Therapy-related Acute Myeloid Leukemia after the Long-term Administration of Low-dose Etoposide for Chronic-type Adult T-cell Leukemia-lymphoma: A Case Report and Literature Review
title_full_unstemmed Therapy-related Acute Myeloid Leukemia after the Long-term Administration of Low-dose Etoposide for Chronic-type Adult T-cell Leukemia-lymphoma: A Case Report and Literature Review
title_short Therapy-related Acute Myeloid Leukemia after the Long-term Administration of Low-dose Etoposide for Chronic-type Adult T-cell Leukemia-lymphoma: A Case Report and Literature Review
title_sort therapy-related acute myeloid leukemia after the long-term administration of low-dose etoposide for chronic-type adult t-cell leukemia-lymphoma: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548683/
https://www.ncbi.nlm.nih.gov/pubmed/28717086
http://dx.doi.org/10.2169/internalmedicine.56.7763
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