An Autopsy Case of Fulminant Hepatitis in a Patient with Multiple Sclerosis Treated by Interferon-Beta-1a

A 44-year-old woman with multiple sclerosis (MS) receiving interferon (IFN)-beta-1a treatment was admitted to a local hospital for severe icterus and liver injury. She was transferred to our university hospital because fulminant hepatitis (FH) was suspected. She was diagnosed with acute-type FH base...

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Detalles Bibliográficos
Autores principales: Yamazaki, Yuichi, Suzuki, Aya, Hirayanagi, Kimitoshi, Tsukagoshi, Yusuke, Uehara, Ryota, Horiguchi, Kazuhiko, Ohyama, Tatsuya, Tomaru, Takuya, Horiguchi, Norio, Nobusawa, Sumihito, Ikota, Hayato, Sato, Ken, Kakizaki, Satoru, Kusano, Motoyasu, Ikeda, Yoshio, Yokoo, Hideaki, Yamada, Masanobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548686/
https://www.ncbi.nlm.nih.gov/pubmed/28717089
http://dx.doi.org/10.2169/internalmedicine.56.7980
Descripción
Sumario:A 44-year-old woman with multiple sclerosis (MS) receiving interferon (IFN)-beta-1a treatment was admitted to a local hospital for severe icterus and liver injury. She was transferred to our university hospital because fulminant hepatitis (FH) was suspected. She was diagnosed with acute-type FH based on hepatic coma, severe liver injury and liver failure, and she received plasma exchange and continuous hemodiafiltration therapy. On hospital day 6, she died from liver failure despite intensive care. An autopsy revealed histological findings consistent with FH. Physicians should monitor the hepatic function of MS patients receiving IFN-beta-1a treatment, as serious events can occur in rare cases.

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