Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites

Activation-induced cytidine deaminase (AID) triggers antibody diversification in B cells by catalysing deamination and subsequently mutating immunoglobulin (Ig) genes. Association of AID with RNA Pol II and occurrence of epigenetic changes during Ig gene diversification suggest participation of AID...

Descripción completa

Detalles Bibliográficos
Autores principales: Rodríguez-Cortez, Virginia C., Martínez-Redondo, Paloma, Català-Moll, Francesc, Rodríguez-Ubreva, Javier, Garcia-Gomez, Antonio, Poorani-Subramani, Ganesh, Ciudad, Laura, Hernando, Henar, Pérez-García, Arantxa, Company, Carlos, Urquiza, José M., Ramiro, Almudena R., Di Noia, Javier M., Vaquero, Alejandro, Ballestar, Esteban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548798/
https://www.ncbi.nlm.nih.gov/pubmed/28790320
http://dx.doi.org/10.1038/s41598-017-07380-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548798/
https://www.ncbi.nlm.nih.gov/pubmed/28790320
http://dx.doi.org/10.1038/s41598-017-07380-9

Ejemplares similares