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Clinical value of integrated‐signature miRNAs in esophageal cancer
MicroRNAs (miRNAs) are crucial regulators of gene expression in tumorigenesis and are of great interest to researchers, but miRNA profiles are often inconsistent between studies. The aim of this study was to confirm candidate miRNA biomarkers for esophageal cancer from integrated‐miRNA expression pr...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548877/ https://www.ncbi.nlm.nih.gov/pubmed/28707457 http://dx.doi.org/10.1002/cam4.1129 |
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author | Zhang, Heng‐Chao Tang, Kai‐Fu |
author_facet | Zhang, Heng‐Chao Tang, Kai‐Fu |
author_sort | Zhang, Heng‐Chao |
collection | PubMed |
description | MicroRNAs (miRNAs) are crucial regulators of gene expression in tumorigenesis and are of great interest to researchers, but miRNA profiles are often inconsistent between studies. The aim of this study was to confirm candidate miRNA biomarkers for esophageal cancer from integrated‐miRNA expression profiling data and TCGA (The Cancer Genome Atlas) data in tissues. Here, we identify five significant miRNAs by a comprehensive analysis in esophageal cancer, and two of them (hsa‐miR‐100‐5p and hsa‐miR‐133b) show better prognoses with significant difference for both 3‐year and 5‐year survival. Additionally, they participate in esophageal cancer occurrence and development according to KEGG and Panther enrichment analyses. Therefore, these five miRNAs may serve as miRNA biomarkers in esophageal cancer. Analysis of differential expression for target genes of these miRNAs may also provide new therapeutic alternatives in esophageal cancer. |
format | Online Article Text |
id | pubmed-5548877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55488772017-08-09 Clinical value of integrated‐signature miRNAs in esophageal cancer Zhang, Heng‐Chao Tang, Kai‐Fu Cancer Med Clinical Cancer Research MicroRNAs (miRNAs) are crucial regulators of gene expression in tumorigenesis and are of great interest to researchers, but miRNA profiles are often inconsistent between studies. The aim of this study was to confirm candidate miRNA biomarkers for esophageal cancer from integrated‐miRNA expression profiling data and TCGA (The Cancer Genome Atlas) data in tissues. Here, we identify five significant miRNAs by a comprehensive analysis in esophageal cancer, and two of them (hsa‐miR‐100‐5p and hsa‐miR‐133b) show better prognoses with significant difference for both 3‐year and 5‐year survival. Additionally, they participate in esophageal cancer occurrence and development according to KEGG and Panther enrichment analyses. Therefore, these five miRNAs may serve as miRNA biomarkers in esophageal cancer. Analysis of differential expression for target genes of these miRNAs may also provide new therapeutic alternatives in esophageal cancer. John Wiley and Sons Inc. 2017-07-14 /pmc/articles/PMC5548877/ /pubmed/28707457 http://dx.doi.org/10.1002/cam4.1129 Text en © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Cancer Research Zhang, Heng‐Chao Tang, Kai‐Fu Clinical value of integrated‐signature miRNAs in esophageal cancer |
title | Clinical value of integrated‐signature miRNAs in esophageal cancer |
title_full | Clinical value of integrated‐signature miRNAs in esophageal cancer |
title_fullStr | Clinical value of integrated‐signature miRNAs in esophageal cancer |
title_full_unstemmed | Clinical value of integrated‐signature miRNAs in esophageal cancer |
title_short | Clinical value of integrated‐signature miRNAs in esophageal cancer |
title_sort | clinical value of integrated‐signature mirnas in esophageal cancer |
topic | Clinical Cancer Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548877/ https://www.ncbi.nlm.nih.gov/pubmed/28707457 http://dx.doi.org/10.1002/cam4.1129 |
work_keys_str_mv | AT zhanghengchao clinicalvalueofintegratedsignaturemirnasinesophagealcancer AT tangkaifu clinicalvalueofintegratedsignaturemirnasinesophagealcancer |