Cargando…
The N-Terminal Region of Fibrillin-1 Mediates a Bipartite Interaction with LTBP1
Fibrillin-1 (FBN1) mutations associated with Marfan syndrome lead to an increase in transforming growth factor β (TGF-β) activation in connective tissues resulting in pathogenic changes including aortic dilatation and dissection. Since FBN1 binds latent TGF-β binding proteins (LTBPs), the major rese...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548924/ https://www.ncbi.nlm.nih.gov/pubmed/28669633 http://dx.doi.org/10.1016/j.str.2017.06.003 |