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Clinical application of simultaneous detection of cystatin C, cathepsin S, and IL-1 in classification of coronary artery disease

Cystatin C, cathepsin S, and IL-1 are three important biomarkers of atherosclerosis. Previous studies emphasized the relationship between individual biomarkers in coronary artery disease (CAD) patients and severity of atherosclerostic lesions of the coronary arteries, while combined cystatin C, cath...

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Autores principales: Yan, Ling, Ding, Shuang, Gu, Bing, Ma, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nanjin Medical University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548992/
https://www.ncbi.nlm.nih.gov/pubmed/28808203
http://dx.doi.org/10.7555/JBR.31.20150152
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author Yan, Ling
Ding, Shuang
Gu, Bing
Ma, Ping
author_facet Yan, Ling
Ding, Shuang
Gu, Bing
Ma, Ping
author_sort Yan, Ling
collection PubMed
description Cystatin C, cathepsin S, and IL-1 are three important biomarkers of atherosclerosis. Previous studies emphasized the relationship between individual biomarkers in coronary artery disease (CAD) patients and severity of atherosclerostic lesions of the coronary arteries, while combined cystatin C, cathepsin S, and IL-1 have not been reported for clinical classification of CAD. We aimed to establish a link between cystatin C, cathepsin S, IL-1 and CAD in this cohort study. Totally 112 subjects were enrolled and divided into the stable angina pectoris group, the unstable angina pectoris group and the acute myocardial infarction (AMI) groups, and 50 healthy adults served as controls. The levels of the three biomarkers were detected by ELISA. The results showed that serum level of cystatin C (mg/L) was higher in CAD patients compared with those in the healthy controls (AMIvs. unstable angina pectoris vs. stable angina pectoris vs. controls: 1.27±0.18 vs. 1.09±0.19 vs. 0.91±0.05 vs. 0.78±0.07, all P<0.01). Cathepsin S (ng/mL) was also significantly different among the groups (AMI vs. unstable angina pectoris vs. stable angina pectoris vs. controls: 67.30±8.36 vs. 56.90±7.16 vs. 49.8±2.72 vs. 67.30±8.36, all P<0.01). IL-1 (pg/mL) was significantly different among the groups as well (AMIvs. unstable angina pectoris vs. stable angina pectoris vs. controls: 2.96±0.57 vs. 2.46±0.24 vs. 2.28±0.09 vs. 2.02±0.13, all P<0.01). Spearman's correlation test revealed positive correlation between cystatin C, cathepsin S, IL-1 and Gensini score (r=0.451, 0.491, 0.397, respectively). It is suggested that simultaneous detection of cystatin C, cathepsin S, and IL-1 in serum may be useful in clinical classification and assessment of severity of CAD.
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spelling pubmed-55489922017-10-05 Clinical application of simultaneous detection of cystatin C, cathepsin S, and IL-1 in classification of coronary artery disease Yan, Ling Ding, Shuang Gu, Bing Ma, Ping J Biomed Res Original Article Cystatin C, cathepsin S, and IL-1 are three important biomarkers of atherosclerosis. Previous studies emphasized the relationship between individual biomarkers in coronary artery disease (CAD) patients and severity of atherosclerostic lesions of the coronary arteries, while combined cystatin C, cathepsin S, and IL-1 have not been reported for clinical classification of CAD. We aimed to establish a link between cystatin C, cathepsin S, IL-1 and CAD in this cohort study. Totally 112 subjects were enrolled and divided into the stable angina pectoris group, the unstable angina pectoris group and the acute myocardial infarction (AMI) groups, and 50 healthy adults served as controls. The levels of the three biomarkers were detected by ELISA. The results showed that serum level of cystatin C (mg/L) was higher in CAD patients compared with those in the healthy controls (AMIvs. unstable angina pectoris vs. stable angina pectoris vs. controls: 1.27±0.18 vs. 1.09±0.19 vs. 0.91±0.05 vs. 0.78±0.07, all P<0.01). Cathepsin S (ng/mL) was also significantly different among the groups (AMI vs. unstable angina pectoris vs. stable angina pectoris vs. controls: 67.30±8.36 vs. 56.90±7.16 vs. 49.8±2.72 vs. 67.30±8.36, all P<0.01). IL-1 (pg/mL) was significantly different among the groups as well (AMIvs. unstable angina pectoris vs. stable angina pectoris vs. controls: 2.96±0.57 vs. 2.46±0.24 vs. 2.28±0.09 vs. 2.02±0.13, all P<0.01). Spearman's correlation test revealed positive correlation between cystatin C, cathepsin S, IL-1 and Gensini score (r=0.451, 0.491, 0.397, respectively). It is suggested that simultaneous detection of cystatin C, cathepsin S, and IL-1 in serum may be useful in clinical classification and assessment of severity of CAD. Nanjin Medical University Press 2017 /pmc/articles/PMC5548992/ /pubmed/28808203 http://dx.doi.org/10.7555/JBR.31.20150152 Text en © 2017 by the Journal of Biomedical Research. All rights reserved This is an open access article under the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited.
spellingShingle Original Article
Yan, Ling
Ding, Shuang
Gu, Bing
Ma, Ping
Clinical application of simultaneous detection of cystatin C, cathepsin S, and IL-1 in classification of coronary artery disease
title Clinical application of simultaneous detection of cystatin C, cathepsin S, and IL-1 in classification of coronary artery disease
title_full Clinical application of simultaneous detection of cystatin C, cathepsin S, and IL-1 in classification of coronary artery disease
title_fullStr Clinical application of simultaneous detection of cystatin C, cathepsin S, and IL-1 in classification of coronary artery disease
title_full_unstemmed Clinical application of simultaneous detection of cystatin C, cathepsin S, and IL-1 in classification of coronary artery disease
title_short Clinical application of simultaneous detection of cystatin C, cathepsin S, and IL-1 in classification of coronary artery disease
title_sort clinical application of simultaneous detection of cystatin c, cathepsin s, and il-1 in classification of coronary artery disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548992/
https://www.ncbi.nlm.nih.gov/pubmed/28808203
http://dx.doi.org/10.7555/JBR.31.20150152
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