Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in Candida albicans

Regulated erroneous protein translation (adaptive mistranslation) increases proteome diversity and produces advantageous phenotypic variability in the human pathogen Candida albicans. It also increases fitness in the presence of fluconazole, but the underlying molecular mechanism is not understood....

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Detalles Bibliográficos
Autores principales: Weil, Tobias, Santamaría, Rodrigo, Lee, Wanseon, Rung, Johan, Tocci, Noemi, Abbey, Darren, Bezerra, Ana R., Carreto, Laura, Moura, Gabriela R., Bayés, Mónica, Gut, Ivo G., Csikasz-Nagy, Attila, Cavalieri, Duccio, Berman, Judith, Santos, Manuel A. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549176/
https://www.ncbi.nlm.nih.gov/pubmed/28808688
http://dx.doi.org/10.1128/mSphere.00167-17

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