Cargando…
Risk of stroke and heart failure attributable to atrial fibrillation in middle-aged and elderly people: Results from a five-year prospective cohort study of Japanese community dwellers
BACKGROUND: The relative and absolute risks of stroke and heart failure attributable to atrial fibrillation (AF) have not been sufficiently examined. METHODS: A prospective study of 23,731 community-dwelling Japanese individuals was conducted. Participants were divided into two groups based on the p...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549250/ https://www.ncbi.nlm.nih.gov/pubmed/28390793 http://dx.doi.org/10.1016/j.je.2016.08.012 |
_version_ | 1783255940226613248 |
---|---|
author | Ohsawa, Masaki Okamura, Tomonori Tanno, Kozo Ogasawara, Kuniaki Itai, Kazuyoshi Yonekura, Yuki Konishi, Kazuki Omama, Shinichi Miyamatsu, Naomi Turin, Tanvir Chowdhury Morino, Yoshihiro Itoh, Tomonori Onoda, Toshiyuki Sakata, Kiyomi Ishibashi, Yasuhiro Makita, Shinji Nakamura, Motoyuki Tanaka, Fumitaka Kuribayashi, Toru Ohta, Mutsuko Okayama, Akira |
author_facet | Ohsawa, Masaki Okamura, Tomonori Tanno, Kozo Ogasawara, Kuniaki Itai, Kazuyoshi Yonekura, Yuki Konishi, Kazuki Omama, Shinichi Miyamatsu, Naomi Turin, Tanvir Chowdhury Morino, Yoshihiro Itoh, Tomonori Onoda, Toshiyuki Sakata, Kiyomi Ishibashi, Yasuhiro Makita, Shinji Nakamura, Motoyuki Tanaka, Fumitaka Kuribayashi, Toru Ohta, Mutsuko Okayama, Akira |
author_sort | Ohsawa, Masaki |
collection | PubMed |
description | BACKGROUND: The relative and absolute risks of stroke and heart failure attributable to atrial fibrillation (AF) have not been sufficiently examined. METHODS: A prospective study of 23,731 community-dwelling Japanese individuals was conducted. Participants were divided into two groups based on the presence or absence of prevalent AF (n = 338 and n = 23,393, respectively). Excess events (EE) due to AF and relative risks (RRs) determined using the non-AF group as the reference for incident stroke and heart failure were estimated using Poisson regression stratified by age groups (middle-aged: 40–69 years old; elderly: 70 years of age or older) after adjustment for sex and age. RESULTS: There were 611 cases of stroke and 98 cases of heart failure during the observation period (131,088 person-years). AF contributed to a higher risk of stroke both in middle-aged individuals (EE 10.4 per 1000 person-years; RR 4.88; 95% confidence interval [CI], 2.88–8.29) and elderly individuals (EE 18.3 per 1000 person-years; RR 3.05; 95% CI, 2.05–4.54). AF also contributed to a higher risk of heart failure in middle-aged individuals (EE 3.7 per 1000 person-years; RR 8.18; 95% CI, 2.41–27.8) and elderly individuals (EE 15.4 per 1000 person-years; RR 7.82; 95% CI, 4.11–14.9). Results obtained from multivariate-adjusted analysis were similar (stroke: EE 8.9 per 1000 person-years; RR 4.40; 95% CI, 2.57–7.55 in middle-aged and EE 17.4 per 1000 person-years; RR 2.97; 95% CI, 1.99–4.43 in elderly individuals; heart failure: EE 3.1 per 1000 person-years; RR 7.22; 95% CI, 2.06–25.3 in middle-aged and EE 14.1 per 1000 person-years; RR 7.41; 95% CI, 3.86–14.2 in elderly individuals). CONCLUSIONS: AF increased the risk of stroke by the same magnitude as that reported previously in Western countries. AF increased the RR of heart failure more than that in Western populations. |
format | Online Article Text |
id | pubmed-5549250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-55492502017-08-16 Risk of stroke and heart failure attributable to atrial fibrillation in middle-aged and elderly people: Results from a five-year prospective cohort study of Japanese community dwellers Ohsawa, Masaki Okamura, Tomonori Tanno, Kozo Ogasawara, Kuniaki Itai, Kazuyoshi Yonekura, Yuki Konishi, Kazuki Omama, Shinichi Miyamatsu, Naomi Turin, Tanvir Chowdhury Morino, Yoshihiro Itoh, Tomonori Onoda, Toshiyuki Sakata, Kiyomi Ishibashi, Yasuhiro Makita, Shinji Nakamura, Motoyuki Tanaka, Fumitaka Kuribayashi, Toru Ohta, Mutsuko Okayama, Akira J Epidemiol Original Article BACKGROUND: The relative and absolute risks of stroke and heart failure attributable to atrial fibrillation (AF) have not been sufficiently examined. METHODS: A prospective study of 23,731 community-dwelling Japanese individuals was conducted. Participants were divided into two groups based on the presence or absence of prevalent AF (n = 338 and n = 23,393, respectively). Excess events (EE) due to AF and relative risks (RRs) determined using the non-AF group as the reference for incident stroke and heart failure were estimated using Poisson regression stratified by age groups (middle-aged: 40–69 years old; elderly: 70 years of age or older) after adjustment for sex and age. RESULTS: There were 611 cases of stroke and 98 cases of heart failure during the observation period (131,088 person-years). AF contributed to a higher risk of stroke both in middle-aged individuals (EE 10.4 per 1000 person-years; RR 4.88; 95% confidence interval [CI], 2.88–8.29) and elderly individuals (EE 18.3 per 1000 person-years; RR 3.05; 95% CI, 2.05–4.54). AF also contributed to a higher risk of heart failure in middle-aged individuals (EE 3.7 per 1000 person-years; RR 8.18; 95% CI, 2.41–27.8) and elderly individuals (EE 15.4 per 1000 person-years; RR 7.82; 95% CI, 4.11–14.9). Results obtained from multivariate-adjusted analysis were similar (stroke: EE 8.9 per 1000 person-years; RR 4.40; 95% CI, 2.57–7.55 in middle-aged and EE 17.4 per 1000 person-years; RR 2.97; 95% CI, 1.99–4.43 in elderly individuals; heart failure: EE 3.1 per 1000 person-years; RR 7.22; 95% CI, 2.06–25.3 in middle-aged and EE 14.1 per 1000 person-years; RR 7.41; 95% CI, 3.86–14.2 in elderly individuals). CONCLUSIONS: AF increased the risk of stroke by the same magnitude as that reported previously in Western countries. AF increased the RR of heart failure more than that in Western populations. Elsevier 2017-04-05 /pmc/articles/PMC5549250/ /pubmed/28390793 http://dx.doi.org/10.1016/j.je.2016.08.012 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Article Ohsawa, Masaki Okamura, Tomonori Tanno, Kozo Ogasawara, Kuniaki Itai, Kazuyoshi Yonekura, Yuki Konishi, Kazuki Omama, Shinichi Miyamatsu, Naomi Turin, Tanvir Chowdhury Morino, Yoshihiro Itoh, Tomonori Onoda, Toshiyuki Sakata, Kiyomi Ishibashi, Yasuhiro Makita, Shinji Nakamura, Motoyuki Tanaka, Fumitaka Kuribayashi, Toru Ohta, Mutsuko Okayama, Akira Risk of stroke and heart failure attributable to atrial fibrillation in middle-aged and elderly people: Results from a five-year prospective cohort study of Japanese community dwellers |
title | Risk of stroke and heart failure attributable to atrial fibrillation in middle-aged and elderly people: Results from a five-year prospective cohort study of Japanese community dwellers |
title_full | Risk of stroke and heart failure attributable to atrial fibrillation in middle-aged and elderly people: Results from a five-year prospective cohort study of Japanese community dwellers |
title_fullStr | Risk of stroke and heart failure attributable to atrial fibrillation in middle-aged and elderly people: Results from a five-year prospective cohort study of Japanese community dwellers |
title_full_unstemmed | Risk of stroke and heart failure attributable to atrial fibrillation in middle-aged and elderly people: Results from a five-year prospective cohort study of Japanese community dwellers |
title_short | Risk of stroke and heart failure attributable to atrial fibrillation in middle-aged and elderly people: Results from a five-year prospective cohort study of Japanese community dwellers |
title_sort | risk of stroke and heart failure attributable to atrial fibrillation in middle-aged and elderly people: results from a five-year prospective cohort study of japanese community dwellers |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549250/ https://www.ncbi.nlm.nih.gov/pubmed/28390793 http://dx.doi.org/10.1016/j.je.2016.08.012 |
work_keys_str_mv | AT ohsawamasaki riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT okamuratomonori riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT tannokozo riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT ogasawarakuniaki riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT itaikazuyoshi riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT yonekurayuki riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT konishikazuki riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT omamashinichi riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT miyamatsunaomi riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT turintanvirchowdhury riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT morinoyoshihiro riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT itohtomonori riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT onodatoshiyuki riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT sakatakiyomi riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT ishibashiyasuhiro riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT makitashinji riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT nakamuramotoyuki riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT tanakafumitaka riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT kuribayashitoru riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT ohtamutsuko riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers AT okayamaakira riskofstrokeandheartfailureattributabletoatrialfibrillationinmiddleagedandelderlypeopleresultsfromafiveyearprospectivecohortstudyofjapanesecommunitydwellers |