Upregulation of TET activity with ascorbic acid induces epigenetic modulation of lymphoma cells

The Ten Eleven Translocation (TET) enzymes have been found to be mutated in both diffuse large B-cell (DLBCL) and peripheral T-cell (PTCL) lymphomas resulting in DNA hypermethylation. Recent studies in embryonal stem cells showed that ascorbic acid (AA) is a cofactor for TET with a binding site at t...

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Detalles Bibliográficos
Autores principales: Shenoy, N, Bhagat, T, Nieves, E, Stenson, M, Lawson, J, Choudhary, G S, Habermann, T, Nowakowski, G, Singh, R, Wu, X, Verma, A, Witzig, T E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549257/
https://www.ncbi.nlm.nih.gov/pubmed/28731456
http://dx.doi.org/10.1038/bcj.2017.65

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