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Hedgehog inhibitor sonidegib potentiates (177)Lu-octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude mice

BACKGROUND: (177)Lu-octreotate can be used to treat somatostatin receptor expressing neuroendocrine tumors. It is highly effective in animal models, but clinical studies have so far only demonstrated low cure rates. Hedgehog inhibitors have shown therapeutic effect as monotherapy in neuroendocrine t...

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Detalles Bibliográficos
Autores principales:	Spetz, Johan, Langen, Britta, Rudqvist, Nils, Parris, Toshima Z., Helou, Khalil, Nilsson, Ola, Forssell-Aronsson, Eva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549301/ https://www.ncbi.nlm.nih.gov/pubmed/28789624 http://dx.doi.org/10.1186/s12885-017-3524-x

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