Pivotal regulators of tissue homeostasis and cancer: macrophages

Macrophages are an essential component of innate immunity and play a vital role in inflammation and host defense. Based on immunological responses, the macrophages are classified into “activated” macrophage (M1 macrophages) participating in the responses of type I helper T (Th1) cells to pathogens a...

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Detalles Bibliográficos
Autores principales: Chen, Yulei, Zhang, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549331/
https://www.ncbi.nlm.nih.gov/pubmed/28804688
http://dx.doi.org/10.1186/s40164-017-0083-4
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author Chen, Yulei
Zhang, Xiaobo
author_facet Chen, Yulei
Zhang, Xiaobo
author_sort Chen, Yulei
collection PubMed
description Macrophages are an essential component of innate immunity and play a vital role in inflammation and host defense. Based on immunological responses, the macrophages are classified into “activated” macrophage (M1 macrophages) participating in the responses of type I helper T (Th1) cells to pathogens and “alternatively activated” macrophages (M2 macrophages) in response to interleukin (IL)-4 and IL-13. In this review, we discuss the origin, classification and function of macrophages. We also discuss the mechanisms underlying polarization of different macrophage subtypes, including transcriptional, epigenetic and post-transcriptional regulation.
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spelling pubmed-55493312017-08-11 Pivotal regulators of tissue homeostasis and cancer: macrophages Chen, Yulei Zhang, Xiaobo Exp Hematol Oncol Review Macrophages are an essential component of innate immunity and play a vital role in inflammation and host defense. Based on immunological responses, the macrophages are classified into “activated” macrophage (M1 macrophages) participating in the responses of type I helper T (Th1) cells to pathogens and “alternatively activated” macrophages (M2 macrophages) in response to interleukin (IL)-4 and IL-13. In this review, we discuss the origin, classification and function of macrophages. We also discuss the mechanisms underlying polarization of different macrophage subtypes, including transcriptional, epigenetic and post-transcriptional regulation. BioMed Central 2017-08-08 /pmc/articles/PMC5549331/ /pubmed/28804688 http://dx.doi.org/10.1186/s40164-017-0083-4 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Chen, Yulei
Zhang, Xiaobo
Pivotal regulators of tissue homeostasis and cancer: macrophages
title Pivotal regulators of tissue homeostasis and cancer: macrophages
title_full Pivotal regulators of tissue homeostasis and cancer: macrophages
title_fullStr Pivotal regulators of tissue homeostasis and cancer: macrophages
title_full_unstemmed Pivotal regulators of tissue homeostasis and cancer: macrophages
title_short Pivotal regulators of tissue homeostasis and cancer: macrophages
title_sort pivotal regulators of tissue homeostasis and cancer: macrophages
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549331/
https://www.ncbi.nlm.nih.gov/pubmed/28804688
http://dx.doi.org/10.1186/s40164-017-0083-4
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AT zhangxiaobo pivotalregulatorsoftissuehomeostasisandcancermacrophages

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