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Use of glycerol-preserved corneas for corneal transplants
PURPOSE: This study was carried out to see the results of glycerol-preserved cornea (GPC) in emergency situation when fresh corneal tissue was not available. The aim was to study the outcome of corneal transplantation using GPC. METHODS: This was a retrospective study. The medical records of all the...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549407/ https://www.ncbi.nlm.nih.gov/pubmed/28724812 http://dx.doi.org/10.4103/ijo.IJO_56_17 |
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author | Gupta, Neeti Upadhyay, Prerna |
author_facet | Gupta, Neeti Upadhyay, Prerna |
author_sort | Gupta, Neeti |
collection | PubMed |
description | PURPOSE: This study was carried out to see the results of glycerol-preserved cornea (GPC) in emergency situation when fresh corneal tissue was not available. The aim was to study the outcome of corneal transplantation using GPC. METHODS: This was a retrospective study. The medical records of all the patients were reviewed, who underwent keratoplasty using “GPC” during the period from October 2011 to December 2015. The indication of keratoplasty, duration of preservation of the GPC, and its outcome were analyzed. Descriptive statistics were applied. RESULTS: Out of the 222 penetrating keratoplasty (PKP) performed over the study period, the GPC was used in 34 patients (males = 31, 91.2%) aged 15–74 years. Therapeutic keratoplasty was performed in all cases in this cohort except one in which tectonic keratoplasty was done. The primary indication of PKP (91.2%) was infectious keratitis. Of these, 20 (64.5%) patients presented with perforated corneal ulcers. Post-PKP, ocular anatomy was preserved in 91.2%, and visual acuity of perception of light positive and accurate projection of rays in all the quadrants was obtained in 76.5% cases. Complications included glaucoma (n = 12, 35.1%), phthisis bulbi (n = 2, 5.9%), and graft reinfection and endophthalmitis after PKP (n = 1, 2.9%). The secondary procedure post-GPC and PKP were trabeculectomy with mitomycin C (n = 7, 58.3%) in patients not controlled on topical antiglaucoma medication. Optical keratoplasty was performed in (n = 3) 8.8% patients and triple procedure in (n = 2) 5.8% patients with good visual acuity postprocedure. CONCLUSIONS: Acellular GPCs are useful in emergency keratoplasty to avoid loss of vision and can save the eye. |
format | Online Article Text |
id | pubmed-5549407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-55494072017-08-21 Use of glycerol-preserved corneas for corneal transplants Gupta, Neeti Upadhyay, Prerna Indian J Ophthalmol Original Article PURPOSE: This study was carried out to see the results of glycerol-preserved cornea (GPC) in emergency situation when fresh corneal tissue was not available. The aim was to study the outcome of corneal transplantation using GPC. METHODS: This was a retrospective study. The medical records of all the patients were reviewed, who underwent keratoplasty using “GPC” during the period from October 2011 to December 2015. The indication of keratoplasty, duration of preservation of the GPC, and its outcome were analyzed. Descriptive statistics were applied. RESULTS: Out of the 222 penetrating keratoplasty (PKP) performed over the study period, the GPC was used in 34 patients (males = 31, 91.2%) aged 15–74 years. Therapeutic keratoplasty was performed in all cases in this cohort except one in which tectonic keratoplasty was done. The primary indication of PKP (91.2%) was infectious keratitis. Of these, 20 (64.5%) patients presented with perforated corneal ulcers. Post-PKP, ocular anatomy was preserved in 91.2%, and visual acuity of perception of light positive and accurate projection of rays in all the quadrants was obtained in 76.5% cases. Complications included glaucoma (n = 12, 35.1%), phthisis bulbi (n = 2, 5.9%), and graft reinfection and endophthalmitis after PKP (n = 1, 2.9%). The secondary procedure post-GPC and PKP were trabeculectomy with mitomycin C (n = 7, 58.3%) in patients not controlled on topical antiglaucoma medication. Optical keratoplasty was performed in (n = 3) 8.8% patients and triple procedure in (n = 2) 5.8% patients with good visual acuity postprocedure. CONCLUSIONS: Acellular GPCs are useful in emergency keratoplasty to avoid loss of vision and can save the eye. Medknow Publications & Media Pvt Ltd 2017-07 /pmc/articles/PMC5549407/ /pubmed/28724812 http://dx.doi.org/10.4103/ijo.IJO_56_17 Text en Copyright: © 2017 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Gupta, Neeti Upadhyay, Prerna Use of glycerol-preserved corneas for corneal transplants |
title | Use of glycerol-preserved corneas for corneal transplants |
title_full | Use of glycerol-preserved corneas for corneal transplants |
title_fullStr | Use of glycerol-preserved corneas for corneal transplants |
title_full_unstemmed | Use of glycerol-preserved corneas for corneal transplants |
title_short | Use of glycerol-preserved corneas for corneal transplants |
title_sort | use of glycerol-preserved corneas for corneal transplants |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549407/ https://www.ncbi.nlm.nih.gov/pubmed/28724812 http://dx.doi.org/10.4103/ijo.IJO_56_17 |
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