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Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study
BACKGROUND: Glutathione plays crucial roles in the detoxification and antioxidant systems of cells and has been used to treat acute poisoning and chronic liver diseases by intravenous injection. This is a first study examining the therapeutic effects of oral administration of glutathione in patients...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549431/ https://www.ncbi.nlm.nih.gov/pubmed/28789631 http://dx.doi.org/10.1186/s12876-017-0652-3 |
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author | Honda, Yasushi Kessoku, Takaomi Sumida, Yoshio Kobayashi, Takashi Kato, Takayuki Ogawa, Yuji Tomeno, Wataru Imajo, Kento Fujita, Koji Yoneda, Masato Kataoka, Koshi Taguri, Masataka Yamanaka, Takeharu Seko, Yuya Tanaka, Saiyu Saito, Satoru Ono, Masafumi Oeda, Satoshi Eguchi, Yuichiro Aoi, Wataru Sato, Kenji Itoh, Yoshito Nakajima, Atsushi |
author_facet | Honda, Yasushi Kessoku, Takaomi Sumida, Yoshio Kobayashi, Takashi Kato, Takayuki Ogawa, Yuji Tomeno, Wataru Imajo, Kento Fujita, Koji Yoneda, Masato Kataoka, Koshi Taguri, Masataka Yamanaka, Takeharu Seko, Yuya Tanaka, Saiyu Saito, Satoru Ono, Masafumi Oeda, Satoshi Eguchi, Yuichiro Aoi, Wataru Sato, Kenji Itoh, Yoshito Nakajima, Atsushi |
author_sort | Honda, Yasushi |
collection | PubMed |
description | BACKGROUND: Glutathione plays crucial roles in the detoxification and antioxidant systems of cells and has been used to treat acute poisoning and chronic liver diseases by intravenous injection. This is a first study examining the therapeutic effects of oral administration of glutathione in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: The study was an open label, single arm, multicenter, pilot trial. Thirty-four NAFLD patients diagnosed using ultrasonography were prospectively evaluated. All patients first underwent intervention to improve their lifestyle habits (diet and exercise) for 3 months, followed by treatment with glutathione (300 mg/day) for 4 months. We evaluated their clinical parameters before and after glutathione treatment. We also quantified liver fat and fibrosis using vibration-controlled transient elastography. The primary outcome of the study was the change in alanine aminotransferase (ALT) levels. RESULTS: Twenty-nine patients finished the protocol. ALT levels significantly decreased following treatment with glutathione for 4 months. In addition, triglycerides, non-esterified fatty acids, and ferritin levels also decreased with glutathione treatment. Following dichotomization of ALT responders based on a median 12.9% decrease from baseline, we found that ALT responders were younger in age and did not have severe diabetes compared with ALT non-responders. The controlled attenuation parameter also decreased in ALT responders. CONCLUSIONS: This pilot study demonstrates the potential therapeutic effects of oral administration of glutathione in practical dose for patients with NAFLD. Large-scale clinical trials are needed to verify its efficacy. TRIAL REGISTRATION: UMIN000011118 (date of registration: July 4, 2013). |
format | Online Article Text |
id | pubmed-5549431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-55494312017-08-11 Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study Honda, Yasushi Kessoku, Takaomi Sumida, Yoshio Kobayashi, Takashi Kato, Takayuki Ogawa, Yuji Tomeno, Wataru Imajo, Kento Fujita, Koji Yoneda, Masato Kataoka, Koshi Taguri, Masataka Yamanaka, Takeharu Seko, Yuya Tanaka, Saiyu Saito, Satoru Ono, Masafumi Oeda, Satoshi Eguchi, Yuichiro Aoi, Wataru Sato, Kenji Itoh, Yoshito Nakajima, Atsushi BMC Gastroenterol Research Article BACKGROUND: Glutathione plays crucial roles in the detoxification and antioxidant systems of cells and has been used to treat acute poisoning and chronic liver diseases by intravenous injection. This is a first study examining the therapeutic effects of oral administration of glutathione in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: The study was an open label, single arm, multicenter, pilot trial. Thirty-four NAFLD patients diagnosed using ultrasonography were prospectively evaluated. All patients first underwent intervention to improve their lifestyle habits (diet and exercise) for 3 months, followed by treatment with glutathione (300 mg/day) for 4 months. We evaluated their clinical parameters before and after glutathione treatment. We also quantified liver fat and fibrosis using vibration-controlled transient elastography. The primary outcome of the study was the change in alanine aminotransferase (ALT) levels. RESULTS: Twenty-nine patients finished the protocol. ALT levels significantly decreased following treatment with glutathione for 4 months. In addition, triglycerides, non-esterified fatty acids, and ferritin levels also decreased with glutathione treatment. Following dichotomization of ALT responders based on a median 12.9% decrease from baseline, we found that ALT responders were younger in age and did not have severe diabetes compared with ALT non-responders. The controlled attenuation parameter also decreased in ALT responders. CONCLUSIONS: This pilot study demonstrates the potential therapeutic effects of oral administration of glutathione in practical dose for patients with NAFLD. Large-scale clinical trials are needed to verify its efficacy. TRIAL REGISTRATION: UMIN000011118 (date of registration: July 4, 2013). BioMed Central 2017-08-08 /pmc/articles/PMC5549431/ /pubmed/28789631 http://dx.doi.org/10.1186/s12876-017-0652-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Honda, Yasushi Kessoku, Takaomi Sumida, Yoshio Kobayashi, Takashi Kato, Takayuki Ogawa, Yuji Tomeno, Wataru Imajo, Kento Fujita, Koji Yoneda, Masato Kataoka, Koshi Taguri, Masataka Yamanaka, Takeharu Seko, Yuya Tanaka, Saiyu Saito, Satoru Ono, Masafumi Oeda, Satoshi Eguchi, Yuichiro Aoi, Wataru Sato, Kenji Itoh, Yoshito Nakajima, Atsushi Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study |
title | Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study |
title_full | Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study |
title_fullStr | Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study |
title_full_unstemmed | Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study |
title_short | Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study |
title_sort | efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549431/ https://www.ncbi.nlm.nih.gov/pubmed/28789631 http://dx.doi.org/10.1186/s12876-017-0652-3 |
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