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Do topical applications of bisphosphonates improve bone formation in oral implantology? A systematic review

BACKGROUND: The aim of this systematic literature review was to evaluate the feasibility of topical bisphosphonate application for preserving/enhancing alveolar bone in oral implantology. MATERIAL AND METHODS: An electronic search was conducted in the PubMed/Medline, EMBASE, Scopus, Web of knowledge...

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Autores principales: Lozano-Carrascal, Naroa, Salomó-Coll, Oscar, Hernández-Alfaro, Federico, Gehrke, Sergio-Alexandre, Gargallo-Albiol, Jordi, Calvo-Guirado, José-Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549526/
https://www.ncbi.nlm.nih.gov/pubmed/28624840
http://dx.doi.org/10.4317/medoral.21887
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author Lozano-Carrascal, Naroa
Salomó-Coll, Oscar
Hernández-Alfaro, Federico
Gehrke, Sergio-Alexandre
Gargallo-Albiol, Jordi
Calvo-Guirado, José-Luis
author_facet Lozano-Carrascal, Naroa
Salomó-Coll, Oscar
Hernández-Alfaro, Federico
Gehrke, Sergio-Alexandre
Gargallo-Albiol, Jordi
Calvo-Guirado, José-Luis
author_sort Lozano-Carrascal, Naroa
collection PubMed
description BACKGROUND: The aim of this systematic literature review was to evaluate the feasibility of topical bisphosphonate application for preserving/enhancing alveolar bone in oral implantology. MATERIAL AND METHODS: An electronic search was conducted in the PubMed/Medline, EMBASE, Scopus, Web of knowledge, and Google-Scholar databases for articles dated from January 2000 to December 2016. Two reviewers assessed the quality of the studies independently. RESULTS: A total of 154 abstracts were identified, of which 18 potentially relevant articles were selected; a final total of nine papers were included for analysis. Comparison of the findings of the selected studies was made difficult by the heterogeneity of the articles, all of them animal research papers that showed heterogeneity in the methodologies used and a high or moderate risk of bias. CONCLUSIONS: The topical application of bisphosphonate solution would appear to favor new bone formation in alveolar defects, and boosts the regenerative capacities of biomaterials resulting in increased bone density. Key words:Alveolar bone, bone regeneration, topical application, biomaterial, bisphosphonates.
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spelling pubmed-55495262017-08-23 Do topical applications of bisphosphonates improve bone formation in oral implantology? A systematic review Lozano-Carrascal, Naroa Salomó-Coll, Oscar Hernández-Alfaro, Federico Gehrke, Sergio-Alexandre Gargallo-Albiol, Jordi Calvo-Guirado, José-Luis Med Oral Patol Oral Cir Bucal Review BACKGROUND: The aim of this systematic literature review was to evaluate the feasibility of topical bisphosphonate application for preserving/enhancing alveolar bone in oral implantology. MATERIAL AND METHODS: An electronic search was conducted in the PubMed/Medline, EMBASE, Scopus, Web of knowledge, and Google-Scholar databases for articles dated from January 2000 to December 2016. Two reviewers assessed the quality of the studies independently. RESULTS: A total of 154 abstracts were identified, of which 18 potentially relevant articles were selected; a final total of nine papers were included for analysis. Comparison of the findings of the selected studies was made difficult by the heterogeneity of the articles, all of them animal research papers that showed heterogeneity in the methodologies used and a high or moderate risk of bias. CONCLUSIONS: The topical application of bisphosphonate solution would appear to favor new bone formation in alveolar defects, and boosts the regenerative capacities of biomaterials resulting in increased bone density. Key words:Alveolar bone, bone regeneration, topical application, biomaterial, bisphosphonates. Medicina Oral S.L. 2017-07 2017-06-18 /pmc/articles/PMC5549526/ /pubmed/28624840 http://dx.doi.org/10.4317/medoral.21887 Text en Copyright: © 2017 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Lozano-Carrascal, Naroa
Salomó-Coll, Oscar
Hernández-Alfaro, Federico
Gehrke, Sergio-Alexandre
Gargallo-Albiol, Jordi
Calvo-Guirado, José-Luis
Do topical applications of bisphosphonates improve bone formation in oral implantology? A systematic review
title Do topical applications of bisphosphonates improve bone formation in oral implantology? A systematic review
title_full Do topical applications of bisphosphonates improve bone formation in oral implantology? A systematic review
title_fullStr Do topical applications of bisphosphonates improve bone formation in oral implantology? A systematic review
title_full_unstemmed Do topical applications of bisphosphonates improve bone formation in oral implantology? A systematic review
title_short Do topical applications of bisphosphonates improve bone formation in oral implantology? A systematic review
title_sort do topical applications of bisphosphonates improve bone formation in oral implantology? a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549526/
https://www.ncbi.nlm.nih.gov/pubmed/28624840
http://dx.doi.org/10.4317/medoral.21887
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