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Cell-free Fetal Nucleic Acid Identifier Markers in Maternal Circulation

From the discovery of cell-free fetal (cff)-DNA in 1997 so far, many studies have been performed on various aspects of cff-nucleic acid. It is undoubted that currently, invasive prenatal diagnosis progresses to the noninvasive test. However, there are many problems. One of the most challenging issue...

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Autores principales: Ramezanzadeh, Mahboubeh, Khosravi, Sharifeh, Salehi, Rasoul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549546/
https://www.ncbi.nlm.nih.gov/pubmed/28828340
http://dx.doi.org/10.4103/2277-9175.211800
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author Ramezanzadeh, Mahboubeh
Khosravi, Sharifeh
Salehi, Rasoul
author_facet Ramezanzadeh, Mahboubeh
Khosravi, Sharifeh
Salehi, Rasoul
author_sort Ramezanzadeh, Mahboubeh
collection PubMed
description From the discovery of cell-free fetal (cff)-DNA in 1997 so far, many studies have been performed on various aspects of cff-nucleic acid. It is undoubted that currently, invasive prenatal diagnosis progresses to the noninvasive test. However, there are many problems. One of the most challenging issues in this field is differentiation and detection of the small amount of cff-nucleic acid in maternal plasma. Many markers and methods have been used for this purpose. This review makes an attempt to review and compare the studies in the field. Six identifier markers including Y-specific sequence, polymorphisms, epigenetic difference, DNA size difference, fetal mRNA, and microRNA as well as the advantages and disadvantages of each marker are discussed. This review provides a relatively perfect set on cff-nucleic acid biomarkers in various physiological and pathological status of pregnancy, helping to review and compare the prior obtained results, and improving designation in future studies.
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spelling pubmed-55495462017-08-21 Cell-free Fetal Nucleic Acid Identifier Markers in Maternal Circulation Ramezanzadeh, Mahboubeh Khosravi, Sharifeh Salehi, Rasoul Adv Biomed Res Review Article From the discovery of cell-free fetal (cff)-DNA in 1997 so far, many studies have been performed on various aspects of cff-nucleic acid. It is undoubted that currently, invasive prenatal diagnosis progresses to the noninvasive test. However, there are many problems. One of the most challenging issues in this field is differentiation and detection of the small amount of cff-nucleic acid in maternal plasma. Many markers and methods have been used for this purpose. This review makes an attempt to review and compare the studies in the field. Six identifier markers including Y-specific sequence, polymorphisms, epigenetic difference, DNA size difference, fetal mRNA, and microRNA as well as the advantages and disadvantages of each marker are discussed. This review provides a relatively perfect set on cff-nucleic acid biomarkers in various physiological and pathological status of pregnancy, helping to review and compare the prior obtained results, and improving designation in future studies. Medknow Publications & Media Pvt Ltd 2017-07-28 /pmc/articles/PMC5549546/ /pubmed/28828340 http://dx.doi.org/10.4103/2277-9175.211800 Text en Copyright: © 2017 Advanced Biomedical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Review Article
Ramezanzadeh, Mahboubeh
Khosravi, Sharifeh
Salehi, Rasoul
Cell-free Fetal Nucleic Acid Identifier Markers in Maternal Circulation
title Cell-free Fetal Nucleic Acid Identifier Markers in Maternal Circulation
title_full Cell-free Fetal Nucleic Acid Identifier Markers in Maternal Circulation
title_fullStr Cell-free Fetal Nucleic Acid Identifier Markers in Maternal Circulation
title_full_unstemmed Cell-free Fetal Nucleic Acid Identifier Markers in Maternal Circulation
title_short Cell-free Fetal Nucleic Acid Identifier Markers in Maternal Circulation
title_sort cell-free fetal nucleic acid identifier markers in maternal circulation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549546/
https://www.ncbi.nlm.nih.gov/pubmed/28828340
http://dx.doi.org/10.4103/2277-9175.211800
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