Continuous IL-23 stimulation drives ILC3 depletion in the upper GI tract and, in combination with TNFα, induces robust activation and a phenotypic switch of ILC3

Mutations in the Interleukin (IL)-23/IL-23 receptor loci are associated with increased inflammatory bowel disease (IBD) susceptibility, and IL-23 neutralization has shown efficacy in early clinical trials. To better understand how an excess of IL-23 affects the gastrointestinal tract, we investigate...

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Detalles Bibliográficos
Autores principales: Paustian, Amanda M. Schmidt, Paez-Cortez, Jesus, Bryant, Shaughn, Westmoreland, Susan, Waegell, Wendy, Kingsbury, Gillian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549730/
https://www.ncbi.nlm.nih.gov/pubmed/28792532
http://dx.doi.org/10.1371/journal.pone.0182841

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