MiR-1254 suppresses HO-1 expression through seed region-dependent silencing and non-seed interaction with TFAP2A transcript to attenuate NSCLC growth

MicroRNAs (miRNAs) are a class of small non-coding RNAs, which direct post-transcriptional gene silencing (PTGS) and function in a vast range of biological events including cancer development. Most miRNAs pair to the target sites through seed region near the 5’ end, leading to mRNA cleavage and/or t...

Descripción completa

Detalles Bibliográficos
Autores principales: Pu, Mengfan, Li, Chenggang, Qi, Xinming, Chen, Jing, Wang, Yizheng, Gao, Lulu, Miao, Lingling, Ren, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549757/
https://www.ncbi.nlm.nih.gov/pubmed/28749936
http://dx.doi.org/10.1371/journal.pgen.1006896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549757/
https://www.ncbi.nlm.nih.gov/pubmed/28749936
http://dx.doi.org/10.1371/journal.pgen.1006896

Ejemplares similares