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MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons

The H1 haplotype of the microtubule-associated protein tau (MAPT) locus is genetically associated with neurodegenerative diseases, including Parkinson's disease (PD), and affects gene expression and splicing. However, the functional impact on neurons of such expression differences has yet to be...

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Detalles Bibliográficos
Autores principales:	Beevers, Joel E., Lai, Mang Ching, Collins, Emma, Booth, Heather D.E., Zambon, Federico, Parkkinen, Laura, Vowles, Jane, Cowley, Sally A., Wade-Martins, Richard, Caffrey, Tara M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549835/ https://www.ncbi.nlm.nih.gov/pubmed/28689993 http://dx.doi.org/10.1016/j.stemcr.2017.06.005

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