Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1

Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing motor neuron disease. Astrocytic factors are known to contribute to motor neuron degeneration and death in ALS. However, the role of astrocyte in promoting motor neuron protein aggregation, a disease hallmark of ALS, remains larg...

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Detalles Bibliográficos
Autores principales: Tripathi, Pratibha, Rodriguez-Muela, Natalia, Klim, Joseph R., de Boer, A. Sophie, Agrawal, Sahil, Sandoe, Jackson, Lopes, Claudia S., Ogliari, Karolyn Sassi, Williams, Luis A., Shear, Matthew, Rubin, Lee L., Eggan, Kevin, Zhou, Qiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549875/
https://www.ncbi.nlm.nih.gov/pubmed/28712846
http://dx.doi.org/10.1016/j.stemcr.2017.06.008

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