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Enhancement of spinal dorsal horn neuron N-methyl-D-aspartate receptor phosphorylation as the mechanism of remifentanil-induced hyperalgesia: Roles of protein kinase C and calcium/calmodulin-dependent protein kinase II
BACKGROUND: Modulation of N-methyl-D-aspartate receptor subunits NR1 and NR2 through phosphorylation mediates opioid-induced hyperalgesia, and activations of protein kinase C and extracellular signal-regulated kinase 1/2 potentiate while activation of calcium/calmodulin-dependent protein kinase II i...
Autores principales: | Li, Sisi, Zeng, Jie, Wan, Xiaoxiao, Yao, Ying, Wu, Yujia, Zhao, Nan, Yu, Cong, Xia, Zhengyuan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549877/ https://www.ncbi.nlm.nih.gov/pubmed/28714352 http://dx.doi.org/10.1177/1744806917723789 |
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