p53 Mediates Failure of Human Definitive Hematopoiesis in Dyskeratosis Congenita

Dyskeratosis congenita (DC) is a bone marrow failure syndrome associated with telomere dysfunction. The progression and molecular determinants of hematopoietic failure in DC remain poorly understood. Here, we use the directed differentiation of human embryonic stem cells harboring clinically relevan...

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Detalles Bibliográficos
Autores principales: Fok, Wilson Chun, Niero, Evandro Luis de Oliveira, Dege, Carissa, Brenner, Kirsten Ann, Sturgeon, Christopher Michael, Batista, Luis Francisco Zirnberger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550027/
https://www.ncbi.nlm.nih.gov/pubmed/28757166
http://dx.doi.org/10.1016/j.stemcr.2017.06.015

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