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Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity

Sequence variation within enhancers plays a major role in both evolution and disease, yet its functional impact on transcription factor (TF) occupancy and enhancer activity remains poorly understood. Here, we assayed the binding of five essential TFs over multiple stages of embryogenesis in two dist...

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Detalles Bibliográficos
Autores principales:	Khoueiry, Pierre, Girardot, Charles, Ciglar, Lucia, Peng, Pei-Chen, Gustafson, E Hilary, Sinha, Saurabh, Furlong, Eileen EM
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Genes and Chromosomes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550276/ https://www.ncbi.nlm.nih.gov/pubmed/28792889 http://dx.doi.org/10.7554/eLife.28440

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